"TNFRSF6B" Related Products

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Recombinant Human TNFRSF6B protein, Fc-tagged

Cat.No.: TNFRSF6B-433H
Product Overview: Recombinant Human TNFRSF6B(Val 30 - His 300) fused with a human IgG1 Fc tag at the C-terminus was expressed in HEK293.
Description: Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) is also known as Decoy Receptor 3 (DcR3), Decoy receptor for Fas ligand and M68, which belongs to the tumor necrosis factor receptor superfamily. TNFRSF6 is a soluble protein which contains four TNFR-Cys repeats. Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain. TNFRSF6B acts as a decoy receptor that competes with death receptors for ligand binding. The protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A.
Source: HEK293
Species: Human
Tag: Fc
Predicted N Terminal: Val 30
Form: Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass: Has a calculated MW of 56.4 kDa. DTT-reduced Protein migrates as 64 kDa in SDS-PAGE due to glycosylation.
Protein length: Val 30 - His 300
Endotoxin: Less than 1.0 EU per μg of the rh TNFRSF6B / DcR3 Fc Chimera by the LAL method.
Purity: >85% as determined by SDS-PAGE.
Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Gene Name: TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy [ Homo sapiens ]
Official Symbol: TNFRSF6B
Synonyms: TNFRSF6B; tumor necrosis factor receptor superfamily, member 6b, decoy; tumor necrosis factor receptor superfamily member 6B; DcR3; DCR3; M68; TR6; decoy receptor 3; decoy receptor for Fas ligand; M68E; DJ583P15.1.1;
Gene ID: 8771
mRNA Refseq: NM_003823
Protein Refseq: NP_003814
MIM: 603361
UniProt ID: O95407
Chromosome Location: 20q13.3
Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function: protein binding; receptor activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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