Active Recombinant Human TNFSF11 Protein, His-tagged
Cat.No. : | TNFSF11-873H |
Product Overview : | Recombinant Human TNFSF11(Gly136-Asp317), transcript variant 1, fused with His tag at N-terminal was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. |
Source : | HEK293 |
Tag : | His |
Form : | 1 x PBS, pH6.5 |
Bio-activity : | Bioactivity was measured by its property to induce osteoclast differentiation in RAW264.7 cells in the presence of 2.5 µg/ml of anti-His tag antibody (Cat. No. 652501). |
Molecular Mass : | 22.7 kDa |
Purity : | >95%, as determined by Coomassie stained SDS-PAGE. |
Concentration : | Protein formulated and vialed at >50 ug/mL in specified buffer |
Gene Name : | TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 [ Homo sapiens ] |
Official Symbol : | TNFSF11 |
Synonyms : | TNFSF11; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand superfamily member 11; CD254; ODF; OPGL; RANKL; TRANCE; osteoprotegerin ligand; osteoclast differentiation factor; TNF-related activation-induced cytokine; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; sOdf; OPTB2; hRANKL2; |
Gene ID : | 8600 |
mRNA Refseq : | NM_003701 |
Protein Refseq : | NP_003692 |
MIM : | 602642 |
UniProt ID : | O14788 |
Products Types
◆ Recombinant Protein | ||
TNFSF11-255M | Active Recombinant Mouse TNFSF11 Protein | +Inquiry |
Tnfsf11-2138M | Recombinant Mouse Tnfsf11 Protein, His-tagged | +Inquiry |
TNFSF11-316H | Recombinant Active Human TNFSF11 Protein, His-tagged(C-ter) | +Inquiry |
TNFSF11-2023M | Recombinant Mouse TNFSF11 Protein, His-tagged | +Inquiry |
TNFSF11-2025R | Recombinant Rat TNFSF11 Protein | +Inquiry |
◆ Lysates | ||
TNFSF11-001CCL | Recombinant Cynomolgus TNFSF11 cell lysate | +Inquiry |
TNFSF11-1586MCL | Recombinant Mouse TNFSF11 cell lysate | +Inquiry |
TNFSF11-1093HCL | Recombinant Human TNFSF11 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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