"TNNI3" Related Products

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Recombinant Human TNNI3 protein, His-tagged

Cat.No.: TNNI3-180H
Product Overview: Recombinant Human TNNI3 fused with His tag was expressed in E. coli.
Description: Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues.
Source: E. coli
Species: Human
Tag: His
Form: Lyophilized from PBS, pH 7.4, 1 mM DTT, 5% trehalose, 0.05% sarcosyl
Molecular Mass: 24.6 kDa
Purity: Greater than 95%
Storage: Store at +4 centigrade for up to 1 month, or aliquot and store at -80 centigrade for up to 12 months. Avoid repeat freeze-thaw cycles.
Gene Name: TNNI3 troponin I type 3 (cardiac) [ Homo sapiens ]
Official Symbol: TNNI3
Synonyms: TNNI3; troponin I type 3 (cardiac); troponin I, cardiac; troponin I, cardiac muscle; CMH7; TNNC1; RCM1; cTnI; CMD2A; CMD1FF; MGC116817;
Gene ID: 7137
mRNA Refseq: NM_000363
Protein Refseq: NP_000354
MIM: 191044
UniProt ID: P19429
Chromosome Location: 19q13.4
Pathway: Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem; Hypertrophic cardiomyopathy (HCM), organism-specific biosystem; Hypertrophic cardiomyopathy (HCM), conserved biosystem; Muscle contraction, organism-specific biosystem;
Function: actin binding; calcium channel inhibitor activity; calcium-dependent protein binding; protein binding; protein domain specific binding; protein kinase binding; troponin C binding; troponin T binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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