Active Recombinant Human Transferrin
Cat.No. : | TF-461H |
Product Overview : | Recombinant Human transferrin was expressed in modifiedhuman 293 cells. |
- Specification
- Gene Information
- Related Products
Cat. No. : | TF-461H |
Description : | Human transferrin is a single-chain glycoprotein. It has two potential N-linked glycosylation sites and one potential O-linked glycosylation site. Transferrin binds two Fe3+ ions, with high affinity (Kd ≈ 10−20 M), together with two synergistically bound CO32- ions. The protein is mainly synthesized in the liver and secreted into the plasma. Lower amounts are also produced in other organs, such as the testis and brain. Transferrin is also capable of acting as a cytokine and has additional functions that may not be related to its iron-carrying capacity. Other roles for transferrin include acting as a neurotrophic factor in myotubule formation and as an angiogenic factor in promoting the migration and invasion of endothelial cells. |
Source : | human 293 cells. |
Molecular Mass : | Under reducing conditions Transferrin migrates as a broad band between 70 and 80 kDa in SDS-PAGE due to post-translational modifications, in particular glycosylation. This compares with unmodified Transferrin that has a predicted monomeric molecular mass of 75.2 kDa. |
PI : | Transferrin separates into a number of isoforms with a pI between 6.0 and 8.0 in 2D PAGE due to post-translational modifications, in particular glycosylation. This compares with the unmodified Transferrin that has a predicted pI of 6.8. |
% Carbohydrate : | Transferrin consists of 5-20% carbohydrate by weight. |
Glycosylation : | Transferrin contains N- and O-linked oligosaccharides. |
Purity : | >95%, as determined by SDS-PAGE and visualized by silver stain. |
Formulation : | When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose. |
Reconstitution : | It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial. |
Storage : | Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. |
Activity : | The activity of Transferrin was measured by its ability to support the growth of HepG2 cells under conditions of reduced serum. Typically 0.1 to 1 g enhances cell proliferation. |
Gene Name : | TF transferrin [ Homo sapiens ] |
Synonyms : | transferrin; PRO1557; PRO2086; DKFZp781D0156; TF; Siderophilin; Transferrin; Beta-1 metal-binding globulin |
Gene ID : | 7018 |
mRNA Refseq : | NM_001063 |
Protein Refseq : | NP_001054 |
MIM : | 190000 |
UniProt ID : | P02787 |
Chromosome Location : | 3q22.1 |
Pathway : | Hemostasis |
Function : | ferric iron binding; metal ion binding; protein binding |
Products Types
◆ Native Protein | ||
TF-31158TH | Native Human TF | +Inquiry |
TF-47C | Native Cattle Transferrin (TRF) Protein | +Inquiry |
TF-002H | Native Human TF Protein, Rhodamine Conjugated | +Inquiry |
◆ Lysates | ||
TF-1208MCL | Recombinant Mouse TF cell lysate | +Inquiry |
TF-2542HCL | Recombinant Human TF cell lysate | +Inquiry |
TF-1554SCL | Recombinant Sus scrofa (Pig) TF cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0813 | TF (Human) Chromogenic Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, abnormalities in TF proteins can serve as diagnostic markers for certain diseases.
Yes, some drugs target TF proteins, especially in the treatment of cancer.
TF proteins can trigger or suppress immune responses, making them relevant in understanding autoimmune diseases.
TF proteins are vital for understanding disease mechanisms and can be targeted for therapeutic purposes.
Yes, various assays, like ELISA and Western blot, can be used to quantify TF protein levels.
Customer Reviews (3)
Write a reviewTheir team of experts is not only knowledgeable about the TF protein but is also dedicated to assisting researchers like myself in overcoming any challenges that may arise.
This high-quality protein is crucial for the success of my experiments, ensuring that I obtain reliable and meaningful scientific findings.
The TF protein is of exceptional quality, making it a perfect fit for my experimental needs.
Ask a Question for All TF Products
Required fields are marked with *
My Review for All TF Products
Required fields are marked with *
Inquiry Basket