| Description : |
This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a "really interesting new gene" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
56.1 kDa |
| AA Sequence : |
MDPTALVEAIVEEVACPICMTFLRE PMSIDCGHSFCHSCLSGLWEIPGES QNWGYTCPLCRAPVQPRNLRPNWQL ANVVEKVRLLRLHPGMGLKGDLCER HGEKLKMFCKEDVLIMCEACSQSPE HEAHSVVPMEDVAWEYKWELHEALE HLKKEQEEAWKLEVGERKRTATWKI QVETRKQSIVWEFEKYQRLLEKKQP PHRQLGAEVAAALASLQREAAETMQ KLELNHSELIQQSQVLWRMIAELKE RSQRPVRWMLQDIQEVLNRSKSWSL QQPEPISLELKTDCRVLGLREILKT YAADVRLDPDTAYSRLIVSEDRKRV HYGDTNQKLPDNPERFYRYNIVLGS QCISSGRHYWEVEVGDRSEWGLGVC KQNVDRKEVVYLSPHYGFWVIRLRK GNEYRAGTDEYPILSLPVPPRRVGI FVDYEAHDISFYNVTDCGSHIFTFP RYPFPGRLLPYFSPCYSIGTNNTAP LAICSLDGEDTRTRPLEQKLISEED LAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
