| Description : |
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca2+-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
52.6 kDa |
| AA Sequence : |
MSAAPGLLHQELSCPLCLQLFDAPV TAECGHSFCRACLGRVAGEPAADGT VLCPCCQAPTRPQALSTNLQLARLV EGLAQVPQGHCEEHLDPLSIYCEQD RALVCGVCASLGSHRGHRLLPAAEA HARLKTQLPQQKLQLQEACMRKEKS VAVLEHQLVEVEETVRQFRGAVGEQ LGKMRVFLAALEGSLDREAERVRGE AGVALRRELGSLNSYLEQLRQMEKV LEEVADKPQTEFLMKYCLVTSRLQK ILAESPPPARLDIQLPIISDDFKFQ VWRKMFRALMPALEELTFDPSSAHP SLVVSSSGRRVECSEQKAPPAGEDP RQFDKAVAVVAHQQLSEGEHYWEVD VGDKPRWALGVIAAEAPRRGRLHAV PSQGLWLLGLREGKILEAHVEAKEP RALRSPERRPTRIGLYLSFGDGVLS FYDASDADALVPLFAFHERLPRPVY PFFDVCWHDKGKNAQPLLLVGPEGA EATRTRPLEQKLISEEDLAANDILD YKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
