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Recombinant Human UCHL1 Protein, Myc/DDK-tagged

Cat.No. : UCHL1-20H
Product Overview : Recombinant human UCHL1 protein with a C-terminal Myc/DDK-tag was expressed in HEK293T.
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  • Gene Information
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Description : The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.
Source : HEK293T
Species : Human
Tag : Myc/DDK
Molecular Mass : 24.6 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles
Storage : Store it at -80 centigrade.
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris. HCl, pH 7.3, 100 mM glycine, 10% glycerol
Gene Name : UCHL1 ubiquitin C-terminal hydrolase L1 [ Homo sapiens (human) ]
Official Symbol : UCHL1
Synonyms : UCHL1; ubiquitin C-terminal hydrolase L1; NDGOA; PARK5; PGP95; SPG79; PGP9.5; Uch-L1; HEL-117; PGP 9.5; HEL-S-53; ubiquitin carboxyl-terminal hydrolase isozyme L1; epididymis luminal protein 117; epididymis secretory protein Li 53; neuron cytoplasmic protein 9.5; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); ubiquitin thioesterase L1; ubiquitin thiolesterase
Gene ID : 7345
mRNA Refseq : NM_004181
Protein Refseq : NP_004172
MIM : 191342
UniProt ID : P09936

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can UCHL1 be used in the early diagnosis of neurodegenerative diseases? 10/19/2021

Early research suggests that changes in UCHL1 levels may be detected in the early stages of some neurodegenerative diseases, but more studies are needed for validation.

Is UCHL1 exclusively associated with neurological functions? 11/22/2019

While UCHL1 is primarily associated with neurological functions, it also has roles in non-neuronal tissues, including certain types of cancer cells.

What are the challenges in using UCHL1 as a diagnostic marker? 09/25/2019

Challenges include the need for standardized assays, variations in UCHL1 levels among individuals, and the influence of other factors on its expression.

Can UCHL1 levels serve as a biomarker for neurodegenerative diseases? 11/22/2017

Yes, elevated or decreased levels of UCHL1 in cerebrospinal fluid or blood may serve as potential biomarkers for certain neurological disorders.

What other conditions or diseases are associated with UCHL1 dysfunction? 07/05/2016

UCHL1 dysfunction has been implicated in conditions such as certain cancers and ischemic stroke.

Customer Reviews (3)

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Reviews
01/22/2021

    Whether it is regarding experimental design, optimization of protocols, or troubleshooting issues, their expertise and prompt customer service help researchers overcome challenges efficiently.

    11/10/2018

      They provide comprehensive technical assistance and guidance throughout the entire research process.

      01/24/2018

        Heir responsiveness to inquiries and willingness to address concerns contribute to a smooth and productive research experience.

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