Recombinant Human USP2 Protein, His-tagged

• Cat.No.: USP2-011H
• Product Overview: Recombinant Human HSPA4 protein (259-605, active catalytic domain) with a C-terminally Histidine tag was expressed in E. coli.

Specification

• Description: This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 50 mM HEPES, pH 8.0, 150 mM sodium chloride, 1 mM DTT, and 0.1 mM EDTA
• Molecular Mass: 40.9 kDa
• Protein length: 259-605
• Purity: ≥95% estimated by SDS-PAGE
• Unit Definition: One unit is defined as the amount of USP2 enzyme required to produce 1 pmol of AMC per minute at room temperature in 50 mM HEPES, pH 7.8, 0.5 mM EDTA, 1 mM DTT,and 0.2% CHAPS
• Stability: ≥ 1 year
• Storage: Store at -80 centigrade
• Shipping: Dry ice in continental US; may vary elsewhere

Gene Information

• Gene Name: USP2 ubiquitin specific peptidase 2 [ Homo sapiens (human) ]
• Official Symbol: USP2
• Synonyms: USP2; ubiquitin specific peptidase 2; USP9; UBP41; ubiquitin carboxyl-terminal hydrolase 2; 41 kDa ubiquitin-specific protease; deubiquitinating enzyme 2; ubiquitin specific protease 12; ubiquitin specific protease 9; ubiquitin thioesterase 2; ubiquitin-specific-processing protease 2; EC 3.4.19.12
• Gene ID: 9099
• mRNA Refseq: NM_001243759
• Protein Refseq: NP_004196
• MIM: 604725
• UniProt ID: O75604