Recombinant Human ZFAND5 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ZFAND5-5312H
• Product Overview: ZFAND5 MS Standard C13 and N15-labeled recombinant protein (NP_001095891) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 23.1 kDa
• AA Sequence: MAQETNQTPGPMLCSTGCGFYGNPR TNGMCSVCYKEHLQRQQNSGRMSPM GTASGSNSPTSDSASVQRADTSLNN CEGAAGSTSEKSRNVPVAALPVTQQ MTEMSISREDKITTPKTEVSEPVVT QPSPSVSQPSTSQSEEKAPELPKPK KNRCFMCRKKVGLTGFDCRCGNLFC GLHRYSDKHNCPYDYKAEAAAKIRK ENPVVVAEKIQRITRTRPLEQKLIS EEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ZFAND5 zinc finger AN1-type containing 5 [ Homo sapiens (human) ]
• Official Symbol: ZFAND5
• Synonyms: ZFAND5; zinc finger, AN1-type domain 5; ZA20D2, zinc finger protein 216, zinc finger, A20 domain containing 2, ZNF216; AN1-type zinc finger protein 5; ZFAND5A; zinc finger protein 216; zinc finger, A20 domain containing 2; zinc finger A20 domain-containing protein 2; ZA20D2; ZNF216
• Gene ID: 7763
• mRNA Refseq: NM_001102421
• Protein Refseq: NP_001095891
• MIM: 604761
• UniProt ID: O76080