Active Recombinant Monkey TNFRSF9 Protein, Fc-tagged, Alexa Fluor 488 conjugated
Cat.No. : | TNFRSF9-551RAF488 |
Product Overview : | Alexa Fluor 488 conjugated recombinant Rhesus TNFRSF9 (NP_001253057.1) (Met1-Gln186) was expressed with the Fc region of human IgG1 at the C-terminus. |
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Description : | CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymph centigradeytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is ass centigradeiated with the tumor necrosis factor receptor–ass centigradeiated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as mon centigradeyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses. In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors. Crosslinking of CD137 on activated T cells has shown promise in enhancing anti-tumor immune responses in murine models, and agonistic anti-CD137 antibodies are currently being tested in phase I clinical trials. |
Source : | HEK293 |
Species : | Monkey |
Tag : | Fc |
Form : | Lyophilized |
Bio-activity : | Measured by its binding ability in a functional ELISA. Immobilized rhesus TNFRSF9-Fc at 10 μg/mL (100 μL/well) can bind biotinylated human TNFSF9, the EC50 of biotinylated human TNFSF9 is 20-100 ng/mL. |
Molecular Mass : | 44 kDa |
Protein length : | Met1-Gln186, 401 |
N-terminal Sequence Analysis : | Leu 24 |
Endotoxin : | < 1.0 EU/ μg protein as determined by the LAL method. |
Purity : | > 95 % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 488 via amines Excitation Wavelength: 488 nm Emission Wavelength: 515-545 nm |
Storage : | Samples are stable for up to twelve months from date of receipt at -70 centigrade. Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Gene Name : | TNFRSF9 TNF receptor superfamily member 9 [ Macaca mulatta (Rhesus monkey) ] |
Official Symbol : | TNFRSF9 |
Synonyms : | TNFRSF9; TNF receptor superfamily member 9; tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9 |
Gene ID : | 708281 |
mRNA Refseq : | NM_001266128 |
Protein Refseq : | NP_001253057 |
UniProt ID : | F6W5G6 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionStudies have found that abnormal expression levels of TNFRSF9 may be associated with certain tumors, autoimmune diseases, and inflammatory diseases.
It has a variety of associations with other proteins and cytokines. For example, it may interact with the NF-kB signaling pathway to regulate the inflammatory response, and it may also interact with apoptosis-related proteins to regulate the apoptosis process.
TNFRSF9 mainly plays an important role in the immune system, as an activating signaling molecule, it is able to stimulate the activation, proliferation and survival of T cells and NK cells.
Inhibitors or activators targeting TNFRSF9 may have potential applications for the treatment of certain tumors, autoimmune diseases, and inflammatory diseases.
The extracellular domain of TNFRSF9 can bind to its ligand, such as 4-1BBL, to initiate signal transduction, which in turn activates downstream signaling pathways.
TNFRSF9 has some potential in tumor immunotherapy. Several antibody drugs have been developed to use the stimulating effects of TNFRSF9 to enhance the activity of immune cells to fight tumors.
Customer Reviews (3)
Write a reviewGood heat resistance, long time treatment at high temperature, still has activity.
The results obtained by SDS-PAGE or Western blot analysis were good.
The purity is good, and the experimental results obtained are accurate.
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