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Recombinant Mouse Arhgap22 Protein, Myc/DDK-tagged

Cat.No. : Arhgap22-1681M
Product Overview : Purified recombinant protein of mouse full-length Rho GTPase activating protein 22 (cDNA clone MGC:47316 IMAGE:4237331), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 55.1 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Arhgap22 Rho GTPase activating protein 22 [ Mus musculus (house mouse) ]
Official Symbol : Arhgap22
Synonyms : Arhgap22; Rho GTPase activating protein 22; RHO; RHOGAP2; p68RacGAP; B230341L19Rik; rho GTPase-activating protein 22; rho-type GTPase-activating protein 22
Gene ID : 239027
mRNA Refseq : NM_153800
Protein Refseq : NP_722495
UniProt ID : Q8BL80

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (9)

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What are the potential signaling pathways influenced by ARHGAP22? 01/22/2023

The exact signaling pathways influenced by ARHGAP22 are still largely unknown. Since it is predicted to possess a RhoGAP domain, it suggests a potential involvement in modulating Rho GTPase-mediated signaling networks, which are crucial for numerous cellular processes ranging from cell migration to cytoskeletal organization.

Are there any known interacting partners of ARHGAP22? 05/19/2022

The protein interaction network of ARHGAP22 is not well-defined. However, it has been reported to potentially interact with the Rho GTPase Cdc42, suggesting a role in regulating Cdc42-mediated signaling pathways.

How does ARHGAP22 expression change under different physiological or pathological conditions? 10/22/2020

The regulation of ARHGAP22 expression under different conditions has not been extensively examined. It is necessary to explore its expression patterns in various physiological and pathological contexts to determine if it is influenced by specific cues or stimuli.

Is ARHGAP22 associated with cancer? 08/23/2020

There is limited evidence regarding the association between ARHGAP22 and cancer. While some studies have identified alterations in ARHGAP22 expression in certain cancer types, the functional implications and clinical significance are still unclear and require further investigation.

Can ARHGAP22 be targeted for therapeutic purposes? 01/30/2019

The therapeutic potential of targeting ARHGAP22 is not yet explored or well-understood due to limited research on its function. Further investigation into its role in cellular processes and disease pathogenesis is necessary before any targeted therapeutic strategies can be considered.

Are there any animal models available to study ARHGAP22 function? 01/27/2019

Currently, there are no specific animal models available to study ARHGAP22 function. Generating animal models, such as knockout mice or zebrafish models, could be valuable in investigating its in vivo role and understanding its significance in biological processes.

Are there any post-translational modifications of ARHGAP22? 06/22/2018

Limited information is available regarding post-translational modifications of ARHGAP22, as research on this protein is relatively scarce. Further studies are needed to explore any potential modifications and their functional consequences.

Is ARHGAP22 associated with any genetic disorders? 11/14/2016

As of now, there are no known genetic disorders specifically linked to ARHGAP22 mutations or dysregulation. However, considering its potential role in cellular processes, it is plausible that future studies may unveil associations between ARHGAP22 variations and certain diseases or disorders.

Is ARHGAP22 expressed in specific tissues or cell types? 09/07/2016

While the specific tissue or cell type expression patterns of ARHGAP22 have not been extensively studied, existing data suggests that it is expressed in a wide range of tissues, including the brain, skeletal muscle, heart, liver, and kidneys.

Customer Reviews (8)

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Reviews
12/08/2021

    ARHGAP22 protein is an enzyme involved in the digestion of carbohydrates, specifically starch.

    09/17/2021

      A reliable manufacturer ensures the production and purification of ARHGAP22 protein, maintaining its quality and purity.

      01/05/2020

        Manufacturers can actively seek collaborations and partnerships with researchers to develop new applications or optimize methodologies using ARHGAP22 protein.

        06/22/2018

          the manufacturer's dedication to continuous improvement and innovation is evident in their ongoing efforts to enhance the ARHGAP22 protein's performance and optimize its applications.

          11/14/2016

            This high-quality protein is crucial for the success of my experiments, ensuring that I obtain reliable and meaningful scientific findings.

            10/22/2016

              Manufacturers should provide detailed information about the production process, quality control measures, and purity assessment methods employed.

              10/10/2016

                Its purity and consistency guarantee accurate and consistent results, allowing for confident data interpretation and analysis.

                06/02/2016

                  The exceptional quality and reliability of the ARHGAP22 protein provided by the manufacturer cannot be overstated.

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