Recombinant Mouse Arhgef9 Protein, Myc/DDK-tagged
Cat.No. : | Arhgef9-1697M |
Product Overview : | Purified recombinant protein of mouse full-length CDC42 guanine nucleotide exchange factor (GEF) 9 (Arhgef9), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
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Description : | Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 61.4 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Arhgef9 CDC42 guanine nucleotide exchange factor (GEF) 9 [ Mus musculus (house mouse) ] |
Official Symbol : | Arhgef9 |
Synonyms : | ARHGEF9; CDC42 guanine nucleotide exchange factor (GEF) 9; rho guanine nucleotide exchange factor 9; collybistin; Cdc42 guanine exchange factor 9; rac/Cdc42 guanine nucleotide exchange factor 9; mKIAA0424; A230067K14; 9630036L12Rik |
Gene ID : | 236915 |
mRNA Refseq : | NM_001033329 |
Protein Refseq : | NP_001028501 |
UniProt ID : | Q3UTH8 |
Products Types
◆ Recombinant Protein | ||
ARHGEF9-430R | Recombinant Rat ARHGEF9 Protein, His (Fc)-Avi-tagged | +Inquiry |
ARHGEF9-704M | Recombinant Mouse ARHGEF9 Protein, His (Fc)-Avi-tagged | +Inquiry |
ARHGEF9-1908M | Recombinant Mouse ARHGEF9 Protein | +Inquiry |
ARHGEF9-791H | Recombinant Human ARHGEF9 protein, GST-tagged | +Inquiry |
ARHGEF9-774R | Recombinant Rat ARHGEF9 Protein | +Inquiry |
◆ Lysates | ||
ARHGEF9-8728HCL | Recombinant Human ARHGEF9 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (17)
Ask a questionARHGEF9 mutations can be inherited in an X-linked or autosomal dominant manner, depending on the specific mutation and disorder. In X-linked inheritance, mutations occur on the X chromosome, and the disorder mainly affects males while females can be carriers. In autosomal dominant inheritance, a single copy of the mutated gene from either parent is sufficient to cause the disorder, and both males and females can be affected. Genetic counseling and testing are essential to understand the inheritance pattern and assess the risk of passing on ARHGEF9-related disorders to offspring.
Yes, ARHGEF9 mutations can be detected through genetic testing. Genetic testing methods such as sequencing of the ARHGEF9 gene can identify specific mutations or variants that may be associated with ARHGEF9-related disorders. This can help provide a definitive diagnosis and guide the management and treatment of individuals with these disorders. Genetic testing may also be used in carrier testing for family members or prenatal testing to assess the risk of having a child with an ARHGEF9-related disorder.
Individuals and families affected by ARHGEF9-related disorders can find support and information through various resources. These may include patient advocacy groups, such as the Pitt Hopkins Research Foundation or the International Rho & GEF Society, that provide support, research updates, and connect families with similar experiences. Online communities and social media groups dedicated to specific disorders associated with ARHGEF9 mutations can also be helpful in connecting with others facing similar challenges. Medical professionals and genetic counselors can provide guidance, education, and help access appropriate healthcare services.
In addition to its function in neuronal development and synaptic function, ARHGEF9 has been implicated in several other cellular processes. It is involved in cell migration, where it regulates actin cytoskeletal rearrangements necessary for cell movement. ARHGEF9 also plays a role in cell adhesion and cell-cell junction formation. Additionally, it has been linked to certain signaling pathways involved in cell proliferation and survival, suggesting its involvement in cellular homeostasis and tissue development.
ARHGEF9 expression can be influenced by various factors and signaling pathways. It can be induced by growth factors, cytokines, and extracellular matrix components. Additionally, certain transcription factors, such as serum response factor (SRF), have been shown to regulate the expression of ARHGEF9.
Animal models such as mice and zebrafish have been utilized to study ARHGEF9-related disorders. These models can help elucidate the physiological effects of ARHGEF9 mutations, explore the underlying mechanisms of the disorders, and evaluate potential therapeutic interventions.
Yes, ARHGEF9 has been implicated in synaptic function. It localizes to dendritic spines, which are small protrusions on neuronal dendrites where excitatory synapses form. ARHGEF9 interacts with various synaptic proteins, including NMDA receptors, Shank scaffolding proteins, and actin-binding proteins, suggesting its involvement in regulating synaptic structure and function. ARHGEF9-mediated Rho GTPase signaling is thought to contribute to spine morphogenesis, synapse formation, and synaptic plasticity.
Yes, ARHGEF9 has been found to interact with various proteins involved in signal transduction and cytoskeletal regulation. Some of the known interacting proteins include Rho GTPases (RhoA and Cdc42), actin-binding proteins (such as profilin and cofilin), scaffold proteins (e.g., IQGAP1), and kinases (like PAK1 and ROCK).
While ARHGEF9's role in cancer is not extensively studied, emerging evidence suggests its involvement in certain cancers. Dysregulation of ARHGEF9 has been associated with increased invasiveness and metastatic potential in breast cancer and lung adenocarcinoma cell lines. Further research is needed to fully understand the mechanisms underlying ARHGEF9's contribution to cancer progression and its potential as a therapeutic target.
While most known mutations in the ARHGEF9 gene are associated with neurodevelopmental disorders, such as XLID9 and Pitt-Hopkins syndrome, recent studies have suggested potential links between ARHGEF9 mutations and other conditions. For example, a study identified ARHGEF9 mutations in individuals with a range of neurodevelopmental disorders, including autism spectrum disorder and epilepsy. Other research has suggested a possible association between ARHGEF9 mutations and certain types of cancer, such as ovarian and colorectal cancer, although more studies are needed to fully understand these connections.
Yes, ARHGEF9 has a paralog called ARHGEF10, which shares similar structural features and functions. Both proteins belong to the ARHGEF family of GEFs and are involved in the regulation of Rho GTPase signaling.
Understanding the role of ARHGEF9 in neurodevelopmental disorders may provide insights into potential therapeutic strategies. Targeting ARHGEF9 or the pathways it regulates could offer new opportunities for drug development aimed at mitigating the symptoms or underlying mechanisms associated with ARHGEF9-related disorders. Additionally, studying ARHGEF9's involvement in cytoskeletal dynamics and cell migration may have implications for cancer metastasis research and the development of anti-metastatic treatments.
As of now, there are no known small molecule inhibitors or activators specifically targeting ARHGEF9. However, research focused on identifying compounds that modulate Rho GTPases or downstream signaling pathways may indirectly impact the activity of ARHGEF9.
Yes, mutations in the ARHGEF9 gene have been associated with several neurodevelopmental disorders. One well-known disorder is X-linked intellectual disability type 9 (XLID9), also known as MRX52, which is characterized by intellectual disability, delayed speech and motor development, and behavioral problems. Another disorder associated with ARHGEF9 mutations is Pitt-Hopkins syndrome (PTHS), a rare genetic condition characterized by intellectual disability, distinctive facial features, and severe neurological abnormalities. ARHGEF9 mutations have also been implicated in a range of other neurodevelopmental disorders.
Yes, mutations or dysregulation of the ARHGEF9 gene have been linked to several neurodevelopmental disorders. Mutations in ARHGEF9 are associated with X-linked intellectual disability, epileptic encephalopathy, and autism spectrum disorder. These findings highlight the importance of ARHGEF9 in proper brain development and function.
Yes, ARHGEF9 can undergo phosphorylation, which can affect its activity and interaction with other proteins. For example, phosphorylation of specific serine residues within the PH domain of ARHGEF9 can regulate its binding to phosphoinositides and modulate its subcellular localization.
Currently, there are no specific drugs or therapies targeting ARHGEF9-related disorders. Treatment for these disorders is generally supportive, focusing on addressing developmental delays, behavioral challenges, and associated medical conditions. However, ongoing research into the underlying molecular mechanisms and pathways involved in ARHGEF9-related disorders may identify potential targets for future therapeutic interventions.
Customer Reviews (8)
Write a reviewTheir technical expertise and prompt customer service have been instrumental in resolving any challenges or questions I encountered throughout my research journey.
Its purity and integrity ensure reliable and reproducible results in a wide range of applications.
In addition to its scientific advantages, the manufacturer of the ARHGEF9 protein stands out for their exceptional support and assistance.
the manufacturer of ARHGEF9 protein provides excellent technical support, ensuring prompt assistance and guidance.
ARHGEF9 protein is of exceptional quality and is highly recommended for meeting experimental needs.
Its ability to modulate the activity of essential signaling pathways involved in these processes makes it a valuable tool for unraveling their complexities.
Their expertise and commitment to customer satisfaction make them a trusted partner in achieving research goals.
It can be effectively employed in in vitro and in vivo studies, offering insights into the intricate mechanisms underlying angiogenesis, lipid metabolism, and cardiovascular diseases.
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