Recombinant Mouse CD274 protein, Fc-tagged
Cat.No. : | CD274-366M |
Product Overview : | Recombinant Mouse CD274 protein (Phe19-Thr238), fused to human IgG1 Fc tag at C-terminus, was expressed in human 293 cells (HEK293). |
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Description : | Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 involve in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. |
Source : | HEK293 |
Species : | Mouse |
Tag : | human IgG1 Fc |
Form : | Lyophilized from 0.22 um filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 51.4 kDa. The protein migrates as 70-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | 220 |
Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | CD274 |
Official Symbol : | CD274 |
Synonyms : | CD274; CD274 antigen; programmed cell death 1 ligand 1; B7 homolog 1; PDCD1 ligand 1; programmed death ligand 1; B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik |
Gene ID : | 60533 |
mRNA Refseq : | NM_021893 |
Protein Refseq : | NP_068693 |
UniProt ID : | Q3U472 |
Products Types
◆ Recombinant Protein | ||
CD274-710H | Recombinant Human CD274 Protein, IgG1 Fc-tagged | +Inquiry |
CD274-712M | Recombinant Mouse CD274 Protein | +Inquiry |
CD274-713M | Recombinant Mouse CD274 Protein, Fc-tagged | +Inquiry |
CD274-365H | Active Recombinant Human CD274 Protein, His & Fc & Avi-tagged, Biotinylated | +Inquiry |
CD274-339H | Recombinant Human CD274 Protein (Met1-Thr239), HIgG1 Fc-tagged, Biotinylated | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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