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Recombinant Mouse CD86 Protein (Met1-Glu245), His-tagged, Biotinylated

Cat.: CD86-799M
Cat.No.: CD86-799M
Product Overview: Recombinant Mouse CD86 Protein (NP_062261.3) (Met1-Glu245) was produced by HEK293 Cells expression system. This protein was expressed with a C-terminal polyhistidine tag. The purified protein was biotinylated in vitro.
Description: CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B7), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. Recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy.
Source: HEK293
Species: Mouse
Tag : His
Predicted N Terminal: Val 24
Form: Lyophilized from sterile Sterile PBS. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass: The recombinant CD86 consists of 233 amino acids and predicts a molecular mass of 26.7 kDa.
Protein length: Met1-Glu245
Endotoxin: < 1.0 EU per μg protein as determined by the LAL method.
Purity: > 95 % as determined by SDS-PAGE.
Stability: Samples are stable for up to twelve months from date of receipt at -70 centigrade.
Storage: Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Gene Name: Cd86 CD86 antigen [ Mus musculus ]
Official Symbol: CD86
Synonyms: CD86; CD86 antigen; B7; B70; MB7; B7-2; B7.2; CLS1; Ly58; ETC-1; Ly-58; MB7-2; Cd28l2; TS/A-2;
Gene ID: 12524
mRNA Refseq: NM_019388
Protein Refseq: NP_062261
UniProt ID: Q91YV7

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