Active Recombinant Mouse Chemokine (C-C motif) Ligand 17

• Cat.No.: Ccl17-463M
• Product Overview: Recombinant Mouse Ccl17protein was expressed in E. coli. Ala24-Pro93.

Specification

• Cat. No.: Ccl17-463M
• Description: Human thymus and activationregulatedchemokine (TARC) also known as Ccl17, is a novel CC chemokine identified usinga signal sequence trap method. Mouse Ccl17 was discovered as a dendritic cell(DC) specific gene by differentiation RNA display. Mouse Ccl17 cDNA encodes ahighly basic 93 amino acid (aa) residue precursor protein with a 23 aa residueputative signal peptide that is cleaved to generate the 70 aa residue mature secretproteins.
• Source: E. coli-derived
• Form: Lyophilized from a 0.2μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
• N-terminalSequence: Ala24
• Molecular Weight: 7.9 kDa
• Activity: Measuredby its ability to chemoattract CEMNKR human Tlymphoblastoid cells. Howell, D.N.et al. (1985) J. Immunol. 134:971. The ED50 for this effect is typically2 10 ng/mL. Measured by its ability to chemoattract human CCR4 transfected BaF3mouse proB cells. The ED50 for this effect is typically 2-8 ng/mL.
• Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
• Purity: >97%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: Reconstituteat 25 μg/mL in sterile PBS that containing at least 0.1% human or bovine serumalbumin.
• Storage: Use a manualdefrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months,-20 to -70°C under sterile conditions after reconstitution.

Gene Information

• Gene Name: Ccl17 chemokine(C-C motif) ligand 17 [ Mus musculus ]
• Official Symbol: Ccl17
• Synonyms: Ccl17; chemokine(C-C motif) ligand 17; Tarc; Abcd-2; Scya17; Scya17l; small inducible cytokinesubfamily A17; CC chemokine ABCD-2; Thymus and activation-regulated chemokine;mCG_12286
• Gene ID: 20295
• mRNA Refseq: NM_011332
• Protein Refseq: NP_035462
• UniProt ID: Q9WUZ6
• Chromosome Location: 8 C5; 8 45.0 cM
• Pathway: Chemokine signaling pathway;Cytokine-cytokine receptor interaction
• Function: CCR4 chemokine receptorbinding; chemokine activity; cytokine activity