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Recombinant Mouse Cyp11a1 Protein, Myc/DDK-tagged

Cat.No. : Cyp11a1-2409M
Product Overview : Purified recombinant protein of mouse full-length cytochrome P450, family 11, subfamily a, polypeptide 1 (Cyp11a1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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  • Gene Information
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Description : A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 60.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 [ Mus musculus (house mouse) ]
Official Symbol : Cyp11a1
Synonyms : Cyp11a1; cytochrome P450, family 11, subfamily a, polypeptide 1; Sc; Scc; csc; Cyp1; cscc; P450s; Cyp11a; Cypxia1; P450scc; D9Ertd411; D9Ertd411e; cholesterol side-chain cleavage enzyme, mitochondrial; cholesterol desmolase; cytochrome P450 11A1; cytochrome P450 side-chain cleavage enzyme; cytochrome P450(scc); cytochrome P450, 11a, cholesterol side-chain cleavage; EC 1.14.15.6
Gene ID : 13070
mRNA Refseq : NM_019779
Protein Refseq : NP_062753
UniProt ID : Q9QZ82

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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