Recombinant Mouse Fgfr1 Protein, Myc/DDK-tagged
Cat.No. : | Fgfr1-3000M |
Product Overview : | Purified recombinant protein of mouse full-length fibroblast growth factor receptor 1 (Fgfr1), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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Description : | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 92.4 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Fgfr1 fibroblast growth factor receptor 1 [ Mus musculus (house mouse) ] |
Official Symbol : | Fgfr1 |
Synonyms : | FGFR1; fibroblast growth factor receptor 1; MFR; c-fgr; bFGF-R-1; proto-oncogene c-Fgr; basic fibroblast growth factor receptor 1; FLG; Eask; Hspy; Flt-2; Fgfr-1; AW208770 |
Gene ID : | 14182 |
mRNA Refseq : | NM_010206 |
Protein Refseq : | NP_034336 |
UniProt ID : | P16092 |
Products Types
◆ Recombinant Protein | ||
FGFR1-91H | Recombinant Active Human FGFR1 Protein (ECD), Fc-His-tagged(C-ter) | +Inquiry |
FGFR1-2054H | Recombinant Human FGFR1 Protein, MYC/DDK-tagged | +Inquiry |
FGFR1-4123H | Recombinant Human FGFR1 Protein, GST-tagged | +Inquiry |
FGFR1-4121H | Active Recombinant Human FGFR1 Protein, GST/His-tagged | +Inquiry |
FGFR1-247H | Recombinant Human FGFR1 Protein, Strep-tagged | +Inquiry |
◆ Lysates | ||
FGFR1-2133MCL | Recombinant Mouse FGFR1 cell lysate | +Inquiry |
FGFR1-2765HCL | Recombinant Human FGFR1 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1557 | U2OS FGFR1 Bioassay Kit | +Inquiry |
Kit-1590 | FGFR1 Functional Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDEFB103A plays a role in maintaining a balanced microbiome by exerting selective antimicrobial activity. Understanding this interaction is crucial for potential applications in microbiome-related disorders.
Research suggests that altered levels of DEFB103A expression may be associated with certain diseases. However, its specific use as a diagnostic marker requires further validation.
While research is ongoing, potential side effects and concerns related to the therapeutic use of DEFB103A or its analogs need to be thoroughly investigated, including any possible immunogenicity.
DEFB103A plays a crucial role in the innate immune system by acting as an antimicrobial peptide. It helps defend the body against a wide range of pathogens, including bacteria, viruses, and fungi.
DEFB103A deficiency has been linked to an increased susceptibility to various infections, particularly those affecting the skin and mucosal surfaces.
Customer Reviews (3)
Write a reviewFGFR1, a calcium-dependent phospholipid-binding protein, plays a crucial role in various cellular processes, making it a valuable tool for investigation.
When combined with the support and quality assurance provided by the manufacturer, researchers can confidently utilize FGFR1 protein to unravel the intricate mechanisms underlying cellular processes, ultimately advancing scientific knowledge.
The manufacturer can contribute to the research process by providing top-quality FGFR1 protein that meets rigorous standards of purity, stability, and reliability.
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