Recombinant Mouse Gmnn Protein, Myc/DDK-tagged

• Cat.No.: Gmnn-3248M
• Product Overview: Purified recombinant protein of mouse full-length geminin (Gmnn), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing. Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 23.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Gmnn geminin [ Mus musculus (house mouse) ]
• Official Symbol: Gmnn
• Synonyms: GMNN; geminin; Gem; AW546347
• Gene ID: 57441
• mRNA Refseq: NM_020567
• Protein Refseq: NP_065592
• UniProt ID: O88513