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Recombinant Mouse Htra1 Protein, Myc/DDK-tagged

Cat.No. : Htra1-3462M
Product Overview : Purified recombinant protein of mouse full-length HtrA serine peptidase 1 (Htra1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, but it is unclear whether it leads to the proteolytic degradation of TGF-beta proteins themselves or not. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 51.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Htra1 HtrA serine peptidase 1 [ Mus musculus (house mouse) ]
Official Symbol : Htra1
Synonyms : HTRA1; HtrA serine peptidase 1; serine protease HTRA1; serine protease 11; protease, serine, 11 (Igf binding); high-temperature requirement A serine peptidase 1; insulin-like growth factor binding protein 5 protease; L56; HTRA; Prss11; RSPP11; AI429470
Gene ID : 56213
mRNA Refseq : NM_019564
Protein Refseq : NP_062510
UniProt ID : Q9R118

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Is there a relationship between the structure and function of HTRA1 protein? 05/26/2023

The structure of the HTRA1 protein determines its function. The serine protease domain is the main functional region of HTRA1 protein, which has catalytic activity and can degrade proteins. In addition, the HTRA1 protein has a number of different domains that are closely related to its function.

Describe the treatment strategy of HTRA1 protein? 09/16/2022

Therapeutic strategies for HTRA1 protein include inhibiting its activity, regulating its expression level, and altering its structure. Several drugs are already undergoing clinical trials to evaluate their efficacy against cancer and other diseases.

How can disease be treated by regulating the expression of HTRA1 protein? 10/28/2021

There are currently no treatments that directly regulate HTRA1 protein expression. However, some diseases can be treated by inhibiting their activity or regulating their expression levels. For example, some drugs can inhibit the activity of the HTRA1 protein to treat cancer or Alzheimer's disease.

Is HTRA1 involved in cell signal transduction? 08/03/2021

HTRA1 protein can be used as a signal transduction molecule by binding to receptors on the cell surface to transmit signals to the cell interior and participate in cell proliferation, differentiation and apoptosis.

How does HTRA1 protein participate in extracellular matrix remodeling? 07/24/2021

This protein can degrade a variety of proteins in the extracellular matrix, including collagen, elastin and fibrin, and thus participate in extracellular matrix remodeling.

What method is used to detect the expression level of HTRA1 protein in biological samples? 06/15/2021

The expression level of HTRA1 protein in biological samples can be detected by immunohistochemistry, western blot and real-time quantitative PCR.

Customer Reviews (3)

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Reviews
06/06/2022

    The structure of HTRA1 is stable and not easy to mutate, which ensures the reliability of the experimental results.

    08/17/2021

      The solubility and ion exchange capacity are very good, which is convenient for subsequent experimental processing and purification.

      11/10/2020

        It is easy to operate and does not require complex operation steps.

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