Recombinant Mouse Htra1 Protein, Myc/DDK-tagged
Cat.No. : | Htra1-3462M |
Product Overview : | Purified recombinant protein of mouse full-length HtrA serine peptidase 1 (Htra1), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
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Description : | Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, but it is unclear whether it leads to the proteolytic degradation of TGF-beta proteins themselves or not. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 51.2 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Htra1 HtrA serine peptidase 1 [ Mus musculus (house mouse) ] |
Official Symbol : | Htra1 |
Synonyms : | HTRA1; HtrA serine peptidase 1; serine protease HTRA1; serine protease 11; protease, serine, 11 (Igf binding); high-temperature requirement A serine peptidase 1; insulin-like growth factor binding protein 5 protease; L56; HTRA; Prss11; RSPP11; AI429470 |
Gene ID : | 56213 |
mRNA Refseq : | NM_019564 |
Protein Refseq : | NP_062510 |
UniProt ID : | Q9R118 |
Products Types
◆ Recombinant Protein | ||
HTRA1-128H | Recombinant Human HTRA1 Mutant (K346I) Protein, Myc/DDK-tagged | +Inquiry |
HTRA1-090H | Recombinant Human HTRA1 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
HTRA1-4381M | Recombinant Mouse HTRA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
HTRA1-5230H | Recombinant Human HTRA1 Protein, GST-tagged | +Inquiry |
HTRA1-1125H | Recombinant Human HTRA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
HTRA1-5329HCL | Recombinant Human HTRA1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe structure of the HTRA1 protein determines its function. The serine protease domain is the main functional region of HTRA1 protein, which has catalytic activity and can degrade proteins. In addition, the HTRA1 protein has a number of different domains that are closely related to its function.
Therapeutic strategies for HTRA1 protein include inhibiting its activity, regulating its expression level, and altering its structure. Several drugs are already undergoing clinical trials to evaluate their efficacy against cancer and other diseases.
There are currently no treatments that directly regulate HTRA1 protein expression. However, some diseases can be treated by inhibiting their activity or regulating their expression levels. For example, some drugs can inhibit the activity of the HTRA1 protein to treat cancer or Alzheimer's disease.
HTRA1 protein can be used as a signal transduction molecule by binding to receptors on the cell surface to transmit signals to the cell interior and participate in cell proliferation, differentiation and apoptosis.
This protein can degrade a variety of proteins in the extracellular matrix, including collagen, elastin and fibrin, and thus participate in extracellular matrix remodeling.
The expression level of HTRA1 protein in biological samples can be detected by immunohistochemistry, western blot and real-time quantitative PCR.
Customer Reviews (3)
Write a reviewThe structure of HTRA1 is stable and not easy to mutate, which ensures the reliability of the experimental results.
The solubility and ion exchange capacity are very good, which is convenient for subsequent experimental processing and purification.
It is easy to operate and does not require complex operation steps.
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