Recombinant Mouse IL21R Protein (ECD), His-tagged(C-ter)

• Cat.No.: Il21r-176M
• Product Overview: Recombinant Mouse IL21R Protein (ECD) with His tag (C-ter) was expressed in HEK293.

Specification

• Description: The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
• Source: HEK293
• Species: Mouse
• Tag: His(C-ter)
• Form: Powder
• Protein Length: Cys20-Pro236
• Endotoxin: Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test.
• Purity: > 97% (by SDS-PAGE)
• Applications: Binding, SDS-PAGE
• Notes: For laboratory research only, not for drug, diagnostic or other use.
• Storage: Lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.
• Storage Buffer: PBS (pH 7.4)
• Reconstitution: Reconstitute to a concentration of 0.1-0.5 mg/ml in sterile distilled water.

Gene Information

• Gene Name: Il21r interleukin 21 receptor [ Mus musculus ]
• Official Symbol: Il21r
• Synonyms: IL21R; interleukin 21 receptor; interleukin-21 receptor; NR8; IL-21R; LR-beta; IL-21 receptor; lymphocyte receptor beta; novel cytokine receptor 8; novel interleukin receptor; NILR
• Gene ID: 60504
• mRNA Refseq: NM_021887
• Protein Refseq: NP_068687