Active Recombinant Mouse Interleukin 22 Receptor, Alpha 2, Fc-tagged

• Cat.No.: Il22ra2-5656M
• Product Overview: RecombinantMouse Il22ra2 protein was expressed in Murine myeloma celllinewith the Fc part of Mouse IgG2A Glu98-Lys330 (C-terminus) and MouseIl22ra2 Thr19-Pro230 (N-terminus).

Specification

• Cat. No.: Il22ra2-5656M
• Description: Il22ra2is a 35-45 kDa secreted glycoprotein belonging to the type II cytokine receptorfamily (CRF). IL-22 signals through a receptor complex consisting of IL-22 R andIL-10 Rβ. Il22ra2 is also a component of the receptor complexes for IL-10,IL-26, IL-28, and IL-29. Il22ra2 is widely expressed, and other cell typesexpress either IL-10 Rα or IL-22 R but not both. The mouse Il22ra2 cDNAencodes a 230 amino acid (aa) precursor that includes a 20 aa signal sequenceand two fibronectin type-III domains.
• Source: Mammalian cells
• Form: Lyophilizedfrom a 0.2 μm filtered solution in PBS.
• N-terminalSequence: Thr19
• MolecularWeight: 51.8 kDa (monomer)
• Activity: Measuredby its binding ability in a functional ELISA. In a 100 μL reaction mixturecontaining biotinylated rmIL-22 at 25 ng/mL and rm Il22ra2/FcChimera dilutions at 0.03-20 μg/mL, the concentration of rm Il22ra2/Fc Chimerathat produces 50% of the optimal binding response is found to be approximately1-4 μg/mL.
• Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
• SDS-PAGE: 60-70kDa, reducing conditions.
• Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: 250 μg/mLin sterile PBS
• Storage: Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution.

Gene Information

• Gene Name: Il22ra2 interleukin 22receptor, alpha 2 [ Mus musculus ]
• Official Symbol: Il22ra2
• Synonyms: Il22ra2; interleukin22 receptor, alpha 2; CRF2X; CRF2-10; CRF2-s1; Il-22bp; interleukin-22receptor subunit alpha-2; IL22BP; IL-22RA2; zcytoR16; IL-22R-alpha-2; IL-22receptor subunit alpha-2; interleukin-22-binding protein; cytokine receptorfamily II soluble 1; cytokine receptor family type 2, soluble 1
• Gene ID: 237310
• mRNA Refseq: NM_178258
• Protein Refseq: NP_839989
• UniProt ID: Q08AV1
• Chromosome Location: 10
• Pathway: Cytokine-cytokinereceptor interaction; Jak-STAT signaling pathway
• Function: interleukin-22binding; interleukin-22 receptor activity; protein binding; receptor activity