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Recombinant Mouse Irf1 Protein, Myc/DDK-tagged

Cat.No. : Irf1-3572M
Product Overview : Purified recombinant protein of mouse full-length interferon regulatory factor 1 (Irf1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Binds to a consensus sequence in gene promoters. Its target genes for transcriptional activation activity are: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA; metabolic enzymes, such as ACOD1/IRG1. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 37.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Irf1 interferon regulatory factor 1 [ Mus musculus (house mouse) ]
Official Symbol : Irf1
Synonyms : IRF1; interferon regulatory factor 1; Irf-1; AU020929
Gene ID : 16362
mRNA Refseq : NM_008390
Protein Refseq : NP_032416
UniProt ID : P15314

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How do changes in IRF1 expression or function affect responses to bacterial infections? 06/19/2022

Variations in IRF1 impact the body's response to bacterial infections.

How does IRF1 impact the pathogenesis of autoimmune diseases? 08/01/2021

IRF1 may play a key role in the development of autoimmune diseases.

What role does IRF1 play in antiviral defense mechanisms? 02/09/2021

IRF1 is crucial in antiviral defenses, enhancing response to viral infections.

How does IRF1 regulate gene expression in the immune response? 12/13/2020

IRF1 activates immune response genes, especially interferon-responsive genes.

What is the effect of IRF1 on tumor suppression and cancer cell proliferation? 07/01/2019

IRF1 acts as a tumor suppressor, inhibiting cancer cell growth.

How does IRF1 influence the development and function of T cells and NK cells? 04/09/2018

IRF1 affects the development and function of T cells and NK cells.

How does IRF1 modulate inflammatory responses and cytokine production? 03/27/2018

IRF1 regulates inflammation and cytokine production.

Customer Reviews (3)

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Reviews
10/19/2021

    Swift protein expression optimization, boosts our research productivity.

    05/03/2020

      Accurate protein structural characterization, a cornerstone of our studies.

      11/01/2019

        High-quality protein sequencing, invaluable for our scientific work.

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