Recombinant Mouse Klhl40 Protein, Myc/DDK-tagged

• Cat.No.: Klhl40-3719M
• Product Overview: Purified recombinant protein of mouse full-length kelch-like 40 (Klhl40), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex. Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 70.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Klhl40 kelch-like 40 [ Mus musculus (house mouse) ]
• Official Symbol: Klhl40
• Synonyms: Klhl40; kelch-like 40; Kbtbd5; 2310024D23Rik; kelch-like protein 40; kelch repeat and BTB (POZ) domain containing 5; kelch repeat and BTB domain-containing protein 5
• Gene ID: 72330
• mRNA Refseq: NM_028202
• Protein Refseq: NP_082478
• UniProt ID: Q9D783