Recombinant Mouse Kmo Protein, Myc/DDK-tagged

• Cat.No.: Kmo-3728M
• Product Overview: Purified recombinant protein of mouse full-length kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (Kmo), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 55 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) [ Mus musculus (house mouse) ]
• Official Symbol: Kmo
• Synonyms: KMO; kynurenine 3-monooxygenase (kynurenine 3-hydroxylase); kynurenine 3-monooxygenase; kynurenine 3-hydroxylase; AI046660
• Gene ID: 98256
• mRNA Refseq: NM_133809
• Protein Refseq: NP_598570
• UniProt ID: Q91WN4