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Recombinant Mouse Mavs Protein, Myc/DDK-tagged

Cat.No. : Mavs-3974M
Product Overview : Purified recombinant protein of mouse full-length mitochondrial antiviral signaling protein (Mavs), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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  • Gene Information
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Description : Required for innate immune defense against viruses Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5) Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 53.4 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Mavs mitochondrial antiviral signaling protein [ Mus musculus (house mouse) ]
Official Symbol : Mavs
Synonyms : MAVS; mitochondrial antiviral signaling protein; mitochondrial antiviral-signaling protein; IFN-beta promoter stimulator-1; virus-induced signaling adapter; CARD adapter inducing interferon beta; mitochondrial anti-viral signaling protein; interferon beta promoter stimulator protein 1; Visa; IPS-1; cardif; D430028G21Rik; MGC25836
Gene ID : 228607
mRNA Refseq : NM_144888
Protein Refseq : NP_659137
UniProt ID : Q8VCF0

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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