Recombinant Mouse Mavs Protein, Myc/DDK-tagged
Cat.No. : | Mavs-3974M |
Product Overview : | Purified recombinant protein of mouse full-length mitochondrial antiviral signaling protein (Mavs), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
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Description : | Required for innate immune defense against viruses Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5) Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 53.4 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Mavs mitochondrial antiviral signaling protein [ Mus musculus (house mouse) ] |
Official Symbol : | Mavs |
Synonyms : | MAVS; mitochondrial antiviral signaling protein; mitochondrial antiviral-signaling protein; IFN-beta promoter stimulator-1; virus-induced signaling adapter; CARD adapter inducing interferon beta; mitochondrial anti-viral signaling protein; interferon beta promoter stimulator protein 1; Visa; IPS-1; cardif; D430028G21Rik; MGC25836 |
Gene ID : | 228607 |
mRNA Refseq : | NM_144888 |
Protein Refseq : | NP_659137 |
UniProt ID : | Q8VCF0 |
Products Types
◆ Recombinant Protein | ||
MAVS-2509R | Recombinant Rhesus Macaque MAVS Protein, His (Fc)-Avi-tagged | +Inquiry |
Mavs-380M | Recombinant Mouse Mavs Protein, His&GST-tagged | +Inquiry |
MAVS-1375H | Recombinant Human MAVS Protein, His (Fc)-Avi-tagged | +Inquiry |
Mavs-381R | Recombinant Rat Mavs Protein, His&GST-tagged | +Inquiry |
MAVS-3255R | Recombinant Rat MAVS Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
MAVS-1909HCL | Recombinant Human MAVS cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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