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Recombinant Mouse Myc Protein, Myc/DDK-tagged

Cat.No. : Myc-4239M
Product Overview : Purified recombinant protein of mouse full-length myelocytomatosis oncogene (Myc), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 50.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Myc myelocytomatosis oncogene [ Mus musculus (house mouse) ]
Official Symbol : Myc
Synonyms : MYC; myelocytomatosis oncogene; myc proto-oncogene protein; c-myc proto-oncogene; transcription factor p64; Myc2; Nird; Niard; bHLHe39; AU016757
Gene ID : 17869
mRNA Refseq : NM_010849
Protein Refseq : NP_034979
UniProt ID : B2RSN1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How does overexpression of the MYC gene affect cardiovascular disease? 11/14/2022

Abnormal expression of MYC gene may affect the occurrence and progression of cardiovascular diseases such as atherosclerosis by regulating the proliferation of vascular smooth muscle cells and increasing the expression of endothelial cell-specific shear-related proteins.

Is the MYC gene a potential target for pancreatic cancer or drug therapy? 06/18/2022

Because of its important promotion role in pancreatic cancer, MYC gene is regarded as one of the potential targets and drug treatment directions for pancreatic cancer treatment, but specific research and related drugs need to be further verified.

How does the MYC gene regulate somatic cell proliferation through cell cycle progression? 05/13/2021

The MYC gene may affect the proliferation of somatic cells by regulating cell cycle progression, such as increasing the S-phase entry of the cell cycle and promoting the G1/S phase transition.

What is the role of the MYC gene in stomach cancer? 03/20/2021

Overexpression and defect of MYC in gastric cancer are associated with the occurrence, progression and prognosis of gastric cancer. MYC translocation and high expression predict a poor prognosis.

Is the MYC gene associated with hematopoietic stem cells? 07/10/2020

MYC gene may be involved in the proliferation and differentiation of hematopoietic stem cells, but the specific mechanism and role still need to be further elucidated.

How does abnormal expression of the MYC gene affect tumor progression? 10/30/2019

Abnormal expression of MYC gene may affect tumor progression and prognosis by activating cell cycle constants, apoptosis inhibition, and enhanced cell mobility.

Customer Reviews (3)

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Reviews
05/19/2022

    The reproducibility of MYC is very good, and the results remain consistent even after repeated experiments several times, which gives me more confidence in the experimental results.

    01/18/2020

      Stability of this protein was still very good when different chemicals or drugs were added, indicating its excellent anti-interference ability and stability.

      10/06/2019

        Due to stability of MYC in Western blot was very good and even prolonged storage did not affect its performance.

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