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Recombinant Mouse Myd88 Protein, Myc/DDK-tagged

Cat.No. : Myd88-4241M
Product Overview : Purified recombinant protein of mouse full-length myeloid differentiation primary response gene 88 (Myd88), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Isoform 2 is defective in its ability to induce IRAK phosphorylation and NF-kappa-B activation and can function as a negative regulator of activation by IL-1 or lipopolysaccharide (LPS). Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. Mediates leukocyte recruitment at the inflammatory site.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 34.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Myd88 myeloid differentiation primary response gene 88 [ Mus musculus (house mouse) ]
Official Symbol : Myd88
Synonyms : MYD88; myeloid differentiation primary response gene 88; myeloid differentiation primary response protein MyD88
Gene ID : 17874
mRNA Refseq : NM_010851
Protein Refseq : NP_034981
UniProt ID : P22366

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does MYD88 contribute to the formation of the Myddosome complex in TLR signaling? 12/13/2021

MYD88 recruits IRAK kinases to form the Myddosome complex, initiating a signaling cascade that culminates in the activation of NF-κB and pro-inflammatory gene expression.

How is the expression of the MYD88 gene regulated at the molecular level? 06/26/2020

MYD88 expression is tightly regulated at the transcriptional level by various factors, including transcription factors and epigenetic modifications.

Explain the role of MYD88 in the recognition of microbial components by the immune system. 03/09/2019

MYD88 is a key mediator in the recognition of microbial components by TLRs, initiating signaling cascades that trigger immune responses against pathogens.

What are the downstream signaling pathways activated by MYD88, and how do they influence immune responses? 10/26/2018

MYD88 activates NF-κB and MAPK signaling pathways, leading to the production of pro-inflammatory cytokines and interferons that orchestrate immune responses.

Explain the role of MYD88 in adaptive immunity and its crosstalk with T and B cell responses. 05/01/2018

MYD88 plays a role in shaping adaptive immune responses by influencing the activation and differentiation of T and B cells, promoting an effective immune defense.

Customer Reviews (3)

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Reviews
02/26/2022

    Top-tier service—customer support's expertise ensured the perfect protein fit.

    01/09/2019

      Dependable quality and service—this recombined protein is a lab favorite.

      05/23/2018

        Rapid delivery, precise results—this product is a lab essential.

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