Recombinant Mouse Neil1 Protein, Myc/DDK-tagged
Cat.No. : | Neil1-4365M |
Product Overview : | Purified recombinant protein of mouse full-length nei endonuclease VIII-like 1 (E. coli) (cDNA clone MGC:49102 IMAGE:5320651), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 28.5 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Neil1 nei endonuclease VIII-like 1 (E. coli) [ Mus musculus (house mouse) ] |
Official Symbol : | Neil1 |
Synonyms : | Neil1; nei endonuclease VIII-like 1 (E. coli); NEH1; Nei1; 2810450N13Rik; endonuclease 8-like 1; DNA glycosylase/AP lyase Neil1; DNA-(apurinic or apyrimidinic site) lyase Neil1; endonuclease VIII; endonuclease VIII-like 1; nei homolog 1; nei-like protein 1; EC 4.2.99.18 |
Gene ID : | 72774 |
mRNA Refseq : | NM_028347 |
Protein Refseq : | NP_082623 |
UniProt ID : | Q8K4Q6 |
Products Types
◆ Recombinant Protein | ||
NEIL1-1498H | Recombinant Human NEIL1 Protein, His (Fc)-Avi-tagged | +Inquiry |
NEIL1-6005M | Recombinant Mouse NEIL1 Protein, His (Fc)-Avi-tagged | +Inquiry |
NEIL1-10566M | Recombinant Mouse NEIL1 Protein | +Inquiry |
NEIL1-4703H | Recombinant Human NEIL1 protein, His-SUMO-tagged | +Inquiry |
NEIL1-3633C | Recombinant Chicken NEIL1 | +Inquiry |
◆ Lysates | ||
NEIL1-3882HCL | Recombinant Human NEIL1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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