Recombinant Mouse Nlrp10 Protein, Myc/DDK-tagged

• Cat.No.: Nlrp10-4434M
• Product Overview: Purified recombinant protein of mouse full-length NLR family, pyrin domain containing 10 (Nlrp10), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Required for immunity against C.albicans infection Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection. Contributes to T-cell-mediated inflammatory responses in the skin Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens. Exhibits both ATPase and GTPase activities.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 76.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Nlrp10 NLR family, pyrin domain containing 10 [ Mus musculus (house mouse) ]
• Official Symbol: Nlrp10
• Synonyms: NLRP10; NLR family, pyrin domain containing 10; NACHT, LRR and PYD domains-containing protein 10; neuronal apoptosis inhibitor protein 10; NACHT, LRR and PYD containing protein 10; NACHT/LRR/pyrin domain-containing protein 10; NACHT, leucine rich repeat and PYD containing 10; PAN5; Pynod; Nalp10; Napl10; 6430548I20Rik
• Gene ID: 244202
• mRNA Refseq: NM_175532
• Protein Refseq: NP_780741
• UniProt ID: Q8CCN1