Recombinant Mouse Nrp1 Protein, Myc/DDK-tagged

• Cat.No.: Nrp1-4502M
• Product Overview: Purified recombinant protein of mouse full-length neuropilin 1 (Nrp1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 103.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Nrp1 neuropilin 1 [ Mus musculus (house mouse) ]
• Official Symbol: Nrp1
• Synonyms: NRP1; neuropilin 1; neuropilin-1; A5 protein; transmembrane receptor; Neuropilin-1 precursor (A5 protein); Nrp; NP-1; Npn1; NPN-1; C530029I03
• Gene ID: 18186
• mRNA Refseq: NM_008737
• Protein Refseq: NP_032763
• UniProt ID: P97333