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Recombinant Mouse Ntrk1 Protein, Myc/DDK-tagged

Cat.No. : Ntrk1-4522M
Product Overview : Purified recombinant protein of mouse full-length neurotrophic tyrosine kinase, receptor, type 1 (Ntrk1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 88.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 [ Mus musculus (house mouse) ]
Official Symbol : Ntrk1
Synonyms : NTRK1; neurotrophic tyrosine kinase, receptor, type 1; high affinity nerve growth factor receptor; Tkr; trk; TrkA; C80751
Gene ID : 18211
mRNA Refseq : NM_001033124
Protein Refseq : NP_001028296
UniProt ID : Q3UFB7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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