Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Mouse Ptpn2 Protein, Myc/DDK-tagged

Cat.No. : Ptpn2-5238M
Product Overview : Purified recombinant protein of mouse full-length protein tyrosine phosphatase, non-receptor type 2 (Ptpn2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
  • Specification
  • Gene Information
  • Related Products
Description : Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 47.4 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Ptpn2 protein tyrosine phosphatase, non-receptor type 2 [ Mus musculus (house mouse) ]
Official Symbol : Ptpn2
Synonyms : PTPN2; protein tyrosine phosphatase, non-receptor type 2; tyrosine-protein phosphatase non-receptor type 2; MPTP; protein-tyrosine phosphatase PTP-2; T cell protein-tyrosine phosphatase; Ptpt; TC-PTP; AI325124
Gene ID : 19255
mRNA Refseq : NM_001127177
Protein Refseq : NP_001120649
UniProt ID : Q06180

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (6)

Ask a question
What is the therapeutic effect of specific PTPN2 inhibitors on inflammatory diseases? 09/30/2022

PTPN2 inhibitors can inhibit certain signaling pathways in the inflammatory response, thereby playing a role in the treatment of inflammatory diseases.

Is there a soluble PTPN2 protein? 01/06/2022

Yes, soluble PTPN2 proteins exist that can be detected in extracellular fluids and may play a role in regulating cell-to-cell communication and signal transduction.

What is the modulating effect of soluble PTPN2 protein on immune response? 03/17/2021

PTPN2 protein can interact with receptors on the surface of immune cells to regulate the activation and function of immune cells, thereby playing a role in regulating immune responses.

What is the role of PTPN2 protein in autoimmune diseases? 01/15/2021

Studies have shown that PTPN2 protein plays a certain role in autoimmune diseases, and its expression level may be related to the occurrence and progression of the disease.

Are specific PTPN2 inhibitors useful for the treatment of autoimmune diseases? 11/02/2020

Specific PTPN2 inhibitors can inhibit certain abnormal signaling pathways in autoimmune diseases, thereby playing a role in the treatment of autoimmune diseases.

How does PTPN2 protein regulate immune response? 04/16/2020

This protein can interact with a variety of immune molecules, such as T cell receptors (TCRs) and B cell receptors (BCRs), to regulate immune responses by regulating their phosphorylation status.

Customer Reviews (3)

Write a review
Reviews
10/06/2022

    Repeatability is good, and the results of multiple experiments are consistent.

    08/10/2022

      The impurities are very well removed and the purity is very high.

      04/14/2021

        Performance is very stable and the price is very reasonable. I would definitely buy this product again.

        Ask a Question for All Ptpn2 Products

        Required fields are marked with *

        My Review for All Ptpn2 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends