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Recombinant Mouse Sarm1 Protein, Myc/DDK-tagged

Cat.No. : Sarm1-5690M
Product Overview : Purified recombinant protein of mouse full-length sterile alpha and HEAT/Armadillo motif containing 1 (Sarm1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : NAD+ hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD+ metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD+ depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD+ into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD+ cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP+, but not other NAD+-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 80.1 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Sarm1 sterile alpha and HEAT/Armadillo motif containing 1 [ Mus musculus (house mouse) ]
Official Symbol : Sarm1
Synonyms : Sarm1; sterile alpha and HEAT/Armadillo motif containing 1; Sarm; C78606; MyD885; A830091I15Rik; NAD(+) hydrolase SARM1; NADP(+) hydrolase SARM1; NADase SARM1; Tir-1 homolog; sterile alpha and TIR motif containing 1; sterile alpha and TIR motif-containing protein 1; EC 3.2.2.6
Gene ID : 237868
mRNA Refseq : NM_172795
Protein Refseq : NP_766383
UniProt ID : Q6PDS3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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