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Recombinant Mouse Slamf7 Protein, Myc/DDK-tagged

Cat.No. : Slamf7-5898M
Product Overview : Purified recombinant protein of mouse full-length SLAM family member 7 (cDNA clone MGC:19034 IMAGE:4168309), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Mediates natural killer (NK) cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on the adapter SH2D1B. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells. May play a role in lymphocyte adhesion. In LPS-activated monocytes negatively regulates production of proinflammatory cytokines.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 32.8 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Slamf7 SLAM family member 7 [ Mus musculus (house mouse) ]
Official Symbol : Slamf7
Synonyms : Slamf7; SLAM family member 7; CS; 19A; CS1; 19A2; 19A24; CRACC; 4930560D03Rik; SLAM family member 7; leukocyte cell-surface antigen; novel Ly9
Gene ID : 75345
mRNA Refseq : NM_144539
Protein Refseq : NP_653122
UniProt ID : Q8BHK6

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the mechanism by which SLAMF7 protein regulates immune responses? 10/13/2022

SLAMF7 protein is involved in regulating immune cell activation, proliferation, and transmission of background signals by binding to activating ligands, such as CD319, thereby influencing the immune response.

What is the potential of combining SLAMF7 protein with immunotherapy? 05/02/2022

By combining with immunotherapy, such as anti-PD-1 antibodies, the immune response can be further enhanced and the anti-tumor effect can be improved. The study of SLAMF7 protein provides a new direction for the development of combinatorial therapeutic strategies.

In which tissues or cells is SLAMF7 protein expressed? 12/13/2021

This protein is mainly expressed in the immune system, including immune cells such as plasma cells, NK cells, and activated T cells.

Does the SLAMF7 protein have a similar role in other types of cancer? 11/14/2020

The role of SLAMF7 protein in other types of cancer is unclear, and further research is needed to determine its potential role in other cancers.

Does SLAMF7 protein have potential in the treatment of multiple myeloma? 05/20/2020

Yes, the SLAMF7 protein has been shown to be a potential therapeutic target. A monoclonal antibody drug targeting SLAMF7 protein (Elotuzumab) has been developed for the treatment of multiple myeloma.

What is the function of SLAMF7 protein in multiple myeloma? 12/11/2019

SLAMF7 protein interacts with NK cells in multiple myeloma and plays a role in inhibiting and controlling tumor growth by activating the anti-tumor activity of NK cells.

Customer Reviews (3)

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Reviews
07/28/2023

    It has a high solubility and can be easily prepared at the desired concentration.

    07/26/2021

      It was found to be well active and could effectively perform the required biological activity experiments.

      04/15/2020

        It was observed that SLAMF7 had good crystallinity, which was conducive to crystallography research.

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