Recombinant Mouse Tardbp Protein, Myc/DDK-tagged
Cat.No. : | Tardbp-6294M |
Product Overview : | Purified recombinant protein of mouse full-length TAR DNA binding protein (Tardbp), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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- Gene Information
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Description : | RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening. In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival. Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins. Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner. Negatively regulates the expression of CDK6. Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 33.3 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Tardbp TAR DNA binding protein [ Mus musculus (house mouse) ] |
Official Symbol : | Tardbp |
Synonyms : | TARDBP; TAR DNA binding protein; TAR DNA-binding protein 43; Tdp43; C85084; TDP-43; 1190002A23Rik |
Gene ID : | 230908 |
mRNA Refseq : | NM_001003899 |
Protein Refseq : | NP_001003899 |
UniProt ID : | Q921F2 |
Products Types
◆ Recombinant Protein | ||
TARDBP-2192H | Recombinant Human TARDBP Protein (1-396 aa), His-tagged | +Inquiry |
TARDBP-22H | Recombinant Human TARDBP Protein | +Inquiry |
TARDBP-41H | Recombinant Human TARDBP Protein (Full length), N-GST-tagged | +Inquiry |
TARDBP-30150TH | Recombinant Human TARDBP | +Inquiry |
TARDBP-39H | Recombinant Human TARDBP protein, GST-tagged | +Inquiry |
◆ Lysates | ||
TARDBP-1251HCL | Recombinant Human TARDBP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionTARDBP may influence the growth and survival of neurons by regulating processes such as protein synthesis and intracellular transport. It may also be involved in regulating neuronal signaling and synaptic function.
The structure of TARDBP determines its ability to bind to RNA and its interaction with ribosomes and other molecules. The study of its structure can help us understand its function and mechanism of action.
There are currently no therapies that directly regulate TARDBP expression. However, its function and interacting molecules can be studied to understand its mechanism of action and discover potential treatments.
In the nervous system, TARDBP may be involved in the development and function of neurons. Studies have shown that its expression levels are associated with neurological disorders such as ALS and FTD.
The expression level of TARDBP can be regulated in a variety of ways, including transcription, post-transcriptional modification, and degradation. These processes may involve various molecules such as transcription factors, regulatory Rnas, and signal transduction pathways.
Studies have shown that TARDBP expression levels are associated with certain neurological diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). These diseases may be related to the abnormal function of TARDBP.
Customer Reviews (3)
Write a reviewThere is no interaction with other reagents, and there is no influence.
The catalytic activity is very good, and the catalytic performance can be maintained in any environment.
TARDBP has good solubility and can be easily dissolved in a variety of buffers.
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