Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Mouse Tardbp Protein, Myc/DDK-tagged

Cat.No. : Tardbp-6294M
Product Overview : Purified recombinant protein of mouse full-length TAR DNA binding protein (Tardbp), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
  • Specification
  • Gene Information
  • Related Products
Description : RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening. In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival. Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins. Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner. Negatively regulates the expression of CDK6. Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 33.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Tardbp TAR DNA binding protein [ Mus musculus (house mouse) ]
Official Symbol : Tardbp
Synonyms : TARDBP; TAR DNA binding protein; TAR DNA-binding protein 43; Tdp43; C85084; TDP-43; 1190002A23Rik
Gene ID : 230908
mRNA Refseq : NM_001003899
Protein Refseq : NP_001003899
UniProt ID : Q921F2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (6)

Ask a question
How does TARDBP affect the growth and survival of neurons? 10/20/2023

TARDBP may influence the growth and survival of neurons by regulating processes such as protein synthesis and intracellular transport. It may also be involved in regulating neuronal signaling and synaptic function.

Does the structure of TARDBP relate to its function? 07/19/2023

The structure of TARDBP determines its ability to bind to RNA and its interaction with ribosomes and other molecules. The study of its structure can help us understand its function and mechanism of action.

Is it possible to treat disease by modulating TARDBP expression? 10/24/2022

There are currently no therapies that directly regulate TARDBP expression. However, its function and interacting molecules can be studied to understand its mechanism of action and discover potential treatments.

What is the function of TARDBP in the nervous system? 10/24/2021

In the nervous system, TARDBP may be involved in the development and function of neurons. Studies have shown that its expression levels are associated with neurological disorders such as ALS and FTD.

Can TARDBP expression be regulated? 06/29/2021

The expression level of TARDBP can be regulated in a variety of ways, including transcription, post-transcriptional modification, and degradation. These processes may involve various molecules such as transcription factors, regulatory Rnas, and signal transduction pathways.

How is the expression level of TARDBP associated with disease? 11/22/2020

Studies have shown that TARDBP expression levels are associated with certain neurological diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). These diseases may be related to the abnormal function of TARDBP.

Customer Reviews (3)

Write a review
Reviews
10/19/2021

    There is no interaction with other reagents, and there is no influence.

    07/10/2021

      The catalytic activity is very good, and the catalytic performance can be maintained in any environment.

      09/22/2020

        TARDBP has good solubility and can be easily dissolved in a variety of buffers.

        Ask a Question for All Tardbp Products

        Required fields are marked with *

        My Review for All Tardbp Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends