Recombinant Mouse Trim6 Protein, Myc/DDK-tagged

• Cat.No.: Trim6-6661M
• Product Overview: Purified recombinant protein of mouse full-length tripartite motif-containing 6 (Trim6), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway. In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys-48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response. Ubiquitinates also MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 56.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Trim6 tripartite motif-containing 6 [ Mus musculus (house mouse) ]
• Official Symbol: Trim6
• Synonyms: TRIM6; tripartite motif-containing 6; tripartite motif-containing protein 6; tripartite motif protein 6; D7Ertd684e; C430046K18Rik
• Gene ID: 94088
• mRNA Refseq: NM_001013616
• Protein Refseq: NP_001013637
• UniProt ID: Q8BGE7