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Recombinant Mouse Txnip Protein, Myc/DDK-tagged

Cat.No. : Txnip-6750M
Product Overview : Purified recombinant protein of mouse full-length thioredoxin interacting protein (Txnip), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
  • Specification
  • Gene Information
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Description : May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 44.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Txnip thioredoxin interacting protein [ Mus musculus (house mouse) ]
Official Symbol : Txnip
Synonyms : TXNIP; thioredoxin interacting protein; thioredoxin-interacting protein; hyperlipidemia 1; thioredoxin binding protein-2; vitamin D3 up-regulated protein 1; upregulated by 1,25-dihydroxyvitamin D-3; THIF; Tbp-2; VDUP1; Hyplip1; AA682105; 1200008J08Rik
Gene ID : 56338
mRNA Refseq : NM_023719
Protein Refseq : NP_076208
UniProt ID : Q8BG60

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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