Recombinant Mouse Uba2 Protein, Myc/DDK-tagged
Cat.No. : | Uba2-6765M |
Product Overview : | Purified recombinant protein of mouse full-length ubiquitin-like modifier activating enzyme 2 (Uba2), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
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Description : | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 70.6 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Uba2 ubiquitin-like modifier activating enzyme 2 [ Mus musculus (house mouse) ] |
Official Symbol : | Uba2 |
Synonyms : | UBA2; ubiquitin-like modifier activating enzyme 2; SUMO-activating enzyme subunit 2; SUMO1 activating enzyme subunit 2; Sumo-1 activating enzyme subunit 2; ubiquitin-like 1-activating enzyme E1B; anthracycline-associated resistance ARX; ubiquitin-like 1 (sentrin) activating enzyme E1B; ubiquitin-like 1 (sentrin) activating enzyme subunit 2; Arx; Sae2; UBA1; Ubl1a2; Uble1b; AA986091 |
Gene ID : | 50995 |
mRNA Refseq : | NM_016682 |
Protein Refseq : | NP_057891 |
UniProt ID : | Q9Z1F9 |
Products Types
◆ Recombinant Protein | ||
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Uba2-521M | Recombinant Mouse Uba2 Protein, His-tagged | +Inquiry |
UBA2-520H | Recombinant Human UBA2 Protein, His-tagged | +Inquiry |
UBA2-12542Z | Recombinant Zebrafish UBA2 | +Inquiry |
UBA2-3515H | Recombinant Human UBA2, GST-tagged | +Inquiry |
◆ Lysates | ||
UBA2-606HCL | Recombinant Human UBA2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionStudies have shown that UBA2 expression levels are associated with the occurrence and development of certain diseases, including cancer and neurodegenerative diseases.
In cancer, UBA2 may contribute to tumorigenesis and development by regulating intracellular protein degradation and signal transduction. It could be a potential target for cancer treatment.
The expression level of UBA2 can be detected by immunohistochemistry, western blot and real-time quantitative PCR.
UBA2 can interact with a variety of other proteins, including ubiquitin ligase, proteolytic enzyme, etc. These interactions enable it to regulate processes such as cell growth, differentiation, and apoptosis.
The structure of UBA2 determines its ability and stability to bind to other proteins. The study of its structure can help us understand its function and mechanism of action.
Therapeutic strategies for UBA2 may include regulating its expression level, inhibiting its enzyme activity, or regulating its associated signal transduction pathways. These methods may have potential applications in the treatment of cancer, neurodegenerative diseases, etc.
Customer Reviews (3)
Write a reviewAfter UBA2 was used, the background of the Western blot was very clean and there was no non-specific signal.
The recombinant protein in the pathogenesis of related diseases was evaluated by animal models or in vitro experiments, and the effect was found to be good.
This protein has good stability and consistency during large-scale production.
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