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Recombinant Mouse Uba2 Protein, Myc/DDK-tagged

Cat.No. : Uba2-6765M
Product Overview : Purified recombinant protein of mouse full-length ubiquitin-like modifier activating enzyme 2 (Uba2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 70.6 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Uba2 ubiquitin-like modifier activating enzyme 2 [ Mus musculus (house mouse) ]
Official Symbol : Uba2
Synonyms : UBA2; ubiquitin-like modifier activating enzyme 2; SUMO-activating enzyme subunit 2; SUMO1 activating enzyme subunit 2; Sumo-1 activating enzyme subunit 2; ubiquitin-like 1-activating enzyme E1B; anthracycline-associated resistance ARX; ubiquitin-like 1 (sentrin) activating enzyme E1B; ubiquitin-like 1 (sentrin) activating enzyme subunit 2; Arx; Sae2; UBA1; Ubl1a2; Uble1b; AA986091
Gene ID : 50995
mRNA Refseq : NM_016682
Protein Refseq : NP_057891
UniProt ID : Q9Z1F9

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the correlation between the expression level of UBA2 and disease? 10/01/2023

Studies have shown that UBA2 expression levels are associated with the occurrence and development of certain diseases, including cancer and neurodegenerative diseases.

What are the specific roles of UBA2 in cancer? 06/07/2023

In cancer, UBA2 may contribute to tumorigenesis and development by regulating intracellular protein degradation and signal transduction. It could be a potential target for cancer treatment.

How to detect UBA2 expression level? 01/22/2023

The expression level of UBA2 can be detected by immunohistochemistry, western blot and real-time quantitative PCR.

How about the interactions of UBA2 with other proteins? 12/19/2022

UBA2 can interact with a variety of other proteins, including ubiquitin ligase, proteolytic enzyme, etc. These interactions enable it to regulate processes such as cell growth, differentiation, and apoptosis.

Does there have relationship between the structure and function of UBA2? 01/15/2022

The structure of UBA2 determines its ability and stability to bind to other proteins. The study of its structure can help us understand its function and mechanism of action.

What are the therapeutic strategies for UBA2? 10/20/2021

Therapeutic strategies for UBA2 may include regulating its expression level, inhibiting its enzyme activity, or regulating its associated signal transduction pathways. These methods may have potential applications in the treatment of cancer, neurodegenerative diseases, etc.

Customer Reviews (3)

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Reviews
05/31/2023

    After UBA2 was used, the background of the Western blot was very clean and there was no non-specific signal.

    10/12/2022

      The recombinant protein in the pathogenesis of related diseases was evaluated by animal models or in vitro experiments, and the effect was found to be good.

      07/04/2021

        This protein has good stability and consistency during large-scale production.

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