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Recombinant Mouse Umod Protein, His/GST-tagged

Cat.No. : Umod-15M
Product Overview : Recombinant Mouse Umod(Glu335~Ser590) fused with His/GST tag at N-terminal was expressed in E. coli.
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Description : Notum is an evolutionarily conserved 60 kDa secreted deacylase that regulates Wnt activity. It is tethered to the cell surface by binding to Glypican-like sulfated proteoglycans, and it functions as a Glypican-dependent Wnt inhibitor. Notum hydrolyzes the palmitoyl moiety from Wnt-3a, making the Wnt more hydrophilic and unable to bind to the Frizzled-8 receptor. It also induces the release of cell surface GPI-anchored proteins such as Glypican-3, Cadherin-13, and uPAR. Notum regulates head regeneration in planaria, head formation and neural induction in Xenopus, and long range activity of hedgehog proteins in Drosophila. It is up-regulated in some human hepatocellular carcinomas and colorectal cancers. Within amino acids 88-458, mouse Notum shares 92% and 99% aa sequence identity with human and rat Notum, respectively.
Source : E. coli
Species : Mouse
Tag : His/GST
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300
Molecular Mass : 60.8kDa
Protein length : Glu335~Ser590
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 95%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS or others.
Gene Name : Umod uromodulin [ Mus musculus ]
Official Symbol : Umod
Synonyms : UMOD; uromodulin; THP; Tamm-Horsfall protein; Tamm-Horsfall glycoprotein; tamm-Horsfall urinary glycoprotein; urehr4; uromucoid; MGC14034;
Gene ID : 22242
mRNA Refseq : NM_009470
Protein Refseq : NP_033496
UniProt ID : Q91X17

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does UMOD deficiency or mutation lead to kidney diseases such as tubulointerstitial nephritis? 12/07/2022

Deficiency or mutations in UMOD can lead to kidney disorders like tubulointerstitial nephritis, affecting kidney structure and function.

What role does UMOD play in salt and water reabsorption in the kidney? 08/21/2022

UMOD plays a crucial role in regulating salt and water reabsorption in the kidneys, affecting fluid balance.

How does UMOD (Uromodulin) contribute to normal kidney function and urinary tract health? 04/16/2022

UMOD is key in maintaining kidney and urinary tract health, influencing urine concentration and kidney function.

What is the impact of UMOD on the risk and progression of chronic kidney disease (CKD)? 03/19/2022

UMOD impacts the development and progression of CKD, influencing kidney filtration and health.

How does UMOD influence the immune response in the urinary tract and kidney? 03/28/2021

UMOD contributes to the immune defense in the urinary system, protecting against infections and inflammation.

How do alterations in UMOD expression or function affect blood pressure regulation and cardiovascular health? 11/23/2018

Changes in UMOD function can impact blood pressure and cardiovascular health, due to its role in kidney function and fluid balance.

What are the mechanisms by which UMOD modulates the formation of kidney stones? 11/07/2018

UMOD affects the formation of kidney stones, potentially influencing their development and composition.

Customer Reviews (3)

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Reviews
03/01/2022

    Efficient protein purification, crucial for our research. Highly recommended.

    11/26/2019

      Accurate protein structural analysis, a critical component of our investigations.

      05/30/2019

        Exceptional protein expression optimization support, greatly enhances our research.

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