Recombinant Mouse Umod Protein, His/GST-tagged
Cat.No. : | Umod-15M |
Product Overview : | Recombinant Mouse Umod(Glu335~Ser590) fused with His/GST tag at N-terminal was expressed in E. coli. |
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Description : | Notum is an evolutionarily conserved 60 kDa secreted deacylase that regulates Wnt activity. It is tethered to the cell surface by binding to Glypican-like sulfated proteoglycans, and it functions as a Glypican-dependent Wnt inhibitor. Notum hydrolyzes the palmitoyl moiety from Wnt-3a, making the Wnt more hydrophilic and unable to bind to the Frizzled-8 receptor. It also induces the release of cell surface GPI-anchored proteins such as Glypican-3, Cadherin-13, and uPAR. Notum regulates head regeneration in planaria, head formation and neural induction in Xenopus, and long range activity of hedgehog proteins in Drosophila. It is up-regulated in some human hepatocellular carcinomas and colorectal cancers. Within amino acids 88-458, mouse Notum shares 92% and 99% aa sequence identity with human and rat Notum, respectively. |
Source : | E. coli |
Species : | Mouse |
Tag : | His/GST |
Form : | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300 |
Molecular Mass : | 60.8kDa |
Protein length : | Glu335~Ser590 |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | > 95% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. If bio-activity of the protein is needed, please check active protein |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Reconstitution : | Reconstitute in PBS or others. |
Gene Name : | Umod uromodulin [ Mus musculus ] |
Official Symbol : | Umod |
Synonyms : | UMOD; uromodulin; THP; Tamm-Horsfall protein; Tamm-Horsfall glycoprotein; tamm-Horsfall urinary glycoprotein; urehr4; uromucoid; MGC14034; |
Gene ID : | 22242 |
mRNA Refseq : | NM_009470 |
Protein Refseq : | NP_033496 |
UniProt ID : | Q91X17 |
Products Types
◆ Recombinant Protein | ||
UMOD-599D | Recombinant Dog UMOD Protein, His-tagged | +Inquiry |
UMOD-2314H | Recombinant Human UMOD Protein, His (Fc)-Avi-tagged | +Inquiry |
Umod-601M | Recombinant Mouse Umod Protein, His/GST-tagged | +Inquiry |
UMOD-6445R | Recombinant Rat UMOD Protein, His-tagged | +Inquiry |
UMOD-37H | Recombinant Human UMOD Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
UMOD-91P | Native Porcine UMOD | +Inquiry |
◆ Lysates | ||
UMOD-1885HCL | Recombinant Human UMOD cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionDeficiency or mutations in UMOD can lead to kidney disorders like tubulointerstitial nephritis, affecting kidney structure and function.
UMOD plays a crucial role in regulating salt and water reabsorption in the kidneys, affecting fluid balance.
UMOD is key in maintaining kidney and urinary tract health, influencing urine concentration and kidney function.
UMOD impacts the development and progression of CKD, influencing kidney filtration and health.
UMOD contributes to the immune defense in the urinary system, protecting against infections and inflammation.
Changes in UMOD function can impact blood pressure and cardiovascular health, due to its role in kidney function and fluid balance.
UMOD affects the formation of kidney stones, potentially influencing their development and composition.
Customer Reviews (3)
Write a reviewEfficient protein purification, crucial for our research. Highly recommended.
Accurate protein structural analysis, a critical component of our investigations.
Exceptional protein expression optimization support, greatly enhances our research.
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