Recombinant Mouse Usp14 Protein, Myc/DDK-tagged

• Cat.No.: Usp14-6865M
• Product Overview: Purified recombinant protein of mouse full-length ubiquitin specific peptidase 14 (Usp14), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 56.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Usp14 ubiquitin specific peptidase 14 [ Mus musculus (house mouse) ]
• Official Symbol: Usp14
• Synonyms: USP14; ubiquitin specific peptidase 14; ubiquitin carboxyl-terminal hydrolase 14; ataxia; ubiquitin thioesterase 14; deubiquitinating enzyme 14; ubiquitin thiolesterase 14; ubiquitin specific protease 14; dUB-type TGT for deubiquitinating enzyme; ubiquitin-specific-processing protease 14; ax; C78769; AW107924; 2610005K12Rik; 2610037B11Rik
• Gene ID: 59025
• mRNA Refseq: NM_021522
• Protein Refseq: NP_067497
• UniProt ID: Q9JMA1