Recombinant Mouse Zfand5 Protein, Myc/DDK-tagged

• Cat.No.: Zfand5-7076M
• Product Overview: Purified recombinant protein of Mouse zinc finger, AN1-type domain 5 (Zfand5), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 23.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Zfand5 zinc finger, AN1-type domain 5 [ Mus musculus (house mouse) ]
• Official Symbol: Zfand5
• Synonyms: ZFAND5; zinc finger, AN1-type domain 5; AN1-type zinc finger protein 5; zinc finger protein 216; zinc finger, A20 domain containing 2; zinc finger A20 domain-containing protein 2; Za20d2; Zfp216; AA415485; 2310057A04Rik; 5830475F03Rik
• Gene ID: 22682
• mRNA Refseq: NM_009551
• Protein Refseq: NP_033577
• UniProt ID: O88878