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Active Recombinant Rat Chemokine (C-X-C motif) Ligand 5

Cat.No. : Cxcl5-445R
Product Overview : RecombinantRat Cxcl5 protein was expressed in E. coli. Ala38-Arg125& Ala38-Lys117.
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Cat. No. : Cxcl5-445R
Description : Cxcl5 is a chemokine originallycloned from LPS stimulated mouse fibroblasts. Rat Cxcl5 sharesapproximately 74% amino acid (aa) sequence identity with mouse Cxcl5 and islikely the rat orthologue to mouse Cxcl5. Rat Cxcl5 cDNAencodes a 130 aa residue precursor with a predicted 37 aa residue signalpeptide and a 93 aa residue mature protein. Among human CXC chemokines, rat Cxcl5 is mostclosely related to human GCP2 and ENA78. Rat Cxcl5 alsodiffers from these two human proteins by having an extended carboxyterminus.
Source : E. coli
Form : Lyophilized from a0.2 um filtered solution in Acetonitrile and TFA with BSA as a carrierprotein.
N-terminalSequence : Ala38
MolecularWeight : 10.1 kDa
Activity : Measuredby its ability to chemoattract human CXCR2 transfected BaF3 mouse proB cells.The ED50 for this effect is typically 0.03 0.15 μg/mL.
Endotoxin Level : <1.0EU per 1 μg of the protein by the LAL method.
Purity : >97%,by SDSPAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstituteat 100μg/mL insterile PBS containing at least 0.1% human or bovine serum albumin.
Storage : Use amanual defrost freezer and avoid repeated freezethaw cycles. 12 months from date ofreceipt, 20 to 70°C as supplied. 1 month, 2 to 8°C under sterileconditions after reconstitution. 3 months, 20 to 70°C under sterileconditions after reconstitution.
Gene Name : Cxcl5 chemokine (C-X-C motif)ligand 5 [ Rattus norvegicus ]
Official Symbol : Cxcl5
Synonyms : Cxcl5; chemokine(C-X-C motif) ligand 5; Cxcl6; C-X-C motif chemokine 5; cytokineLIX; CXC chemokine LIX; small-inducible cytokine B5; chemokine (C-X-C motif)ligand 6 (granulocyte chemotactic protein 2)
Gene ID : 60665
mRNA Refseq : NM_022214
Protein Refseq : NP_071550
UniProt ID : P97885
Chromosome Location : 14
Pathway : Chemokine receptorsbind chemokines; Chemokine signaling pathway; Class A/1 (Rhodopsin-likereceptors); G alpha (i) signalling events; GPCR downstream signaling; GPCRligand binding; Peptide ligand-binding receptors; Pertussis; Rheumatoidarthritis; Signal Transduction; Signaling by GPCR
Function : chemokine activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does CXCL5 contribute to tumor progression and metastasis? 12/04/2021

CXCL5 is implicated in promoting tumor growth and metastasis by facilitating the migration of cancer cells and modulating the tumor microenvironment.

Are there any ongoing clinical trials targeting CXCL5 for therapeutic purposes? 05/15/2020

Several clinical trials are exploring the efficacy of drugs that modulate CXCL5 levels in various diseases, including cancer, autoimmune disorders, and inflammatory conditions.

In what ways does CXCL5 participate in the regulation of angiogenesis? 03/01/2019

CXCL5 has been identified as a regulator of angiogenesis, influencing the formation of new blood vessels, a process crucial for tumor growth and wound healing.

How can CXCL5 be harnessed for regenerative medicine purposes? 03/31/2018

CXCL5's role in recruiting cells to damaged tissues makes it a potential candidate for enhancing regenerative medicine approaches, such as tissue repair and wound healing.

In what ways can CXCL5 be used as a biomarker in clinical diagnostics? 03/19/2016

CXCL5 levels can be measured in blood or tissue samples to assess the extent of inflammation, aiding in the diagnosis and monitoring of various diseases.

Customer Reviews (3)

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Reviews
06/25/2021

    Its versatility and reliability make it an indispensable asset for scientists seeking to explore the complexities of various biological systems.

    01/13/2021

      Its stability and functional attributes ensure reliable imaging and facilitate the elucidation of complex protein structures.

      03/28/2018

        The CXCL5 protein is known for its exceptional quality, making it a highly suitable choice for meeting diverse experimental needs.

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