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Recombinant Rat Hif1a protein, His/S-tagged

Cat.No. : Hif1a-153R
Product Overview : Recombinant Rat Hif1a fused with His/S tag was expressed in E. coli.
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Description : Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator(ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified.
Source : E. coli
Species : Rat
Tag : His/S
Form : Lyophilized from sterile PBS, pH 7.4
Purity : > 95 % as determined by SDS-PAGE
Storage : Store at -70 centigrade. Avoid repeated freeze/thaw cycles.
Gene Name : Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [ Rattus norvegicus ]
Official Symbol : Hif1a
Synonyms : HIF1A; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1-alpha; HIF1 alpha; HIF1-alpha; HIF-1 alpha; HIF-1-alpha; hypoxia-inducible factor 1 alpha; hypoxia inducible factor 1, alpha subunit; MOP1;
Gene ID : 29560
mRNA Refseq : NM_024359
Protein Refseq : NP_077335
UniProt ID : O35800
Chromosome Location : 6q24
Pathway : Adipogenesis, organism-specific biosystem; Pathways in cancer, organism-specific biosystem; Renal cell carcinoma, organism-specific biosystem; Renal cell carcinoma, conserved biosystem; mTOR signaling pathway, organism-specific biosystem; mTOR signaling pathway, conserved biosystem;
Function : DNA binding; DNA binding; Hsp90 protein binding; double-stranded DNA binding; histone acetyltransferase binding; histone acetyltransferase binding; histone deacetylase binding; protein binding transcription factor activity; protein complex binding; protein heterodimerization activity; protein heterodimerization activity; protein heterodimerization activity; protein kinase binding; sequence-specific DNA binding; sequence-specific DNA binding; contributes_to sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; contributes_to sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; signal transducer activity; transcription factor binding; transcription regulatory region DNA binding; transcription regulatory region DNA binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does HIF1A contribute to metabolic reprogramming in cells? 09/01/2022

HIF1A shifts cellular metabolism from oxidative phosphorylation to glycolysis, conserving oxygen but producing less energy.

How does HIF1A influence immune responses under hypoxic conditions? 07/10/2021

HIF1A modulates immune cell function, influencing responses like inflammation and immune cell migration in hypoxic tissues.

What role does HIF1A play in angiogenesis? 04/28/2021

HIF1A upregulates the expression of angiogenic factors, promoting blood vessel formation to improve oxygen supply.

In what way is HIF1A implicated in cancer progression? 09/14/2020

In cancer, HIF1A promotes tumor growth, survival, and metastasis under low oxygen conditions.

What is the primary function of HIF1A in response to hypoxia? 08/27/2018

HIF1A activates the transcription of genes involved in oxygen delivery and metabolic adaptation to hypoxia.

How is HIF1A regulated at the post-translational level? 06/17/2018

Under normoxic conditions, HIF1A is rapidly degraded, but under hypoxia, it stabilizes, translocates to the nucleus, and activates target genes.

What therapeutic strategies are being developed to target HIF1A in diseases? 02/13/2018

Therapeutic strategies targeting HIF1A aim to inhibit its activity in cancer or enhance it in conditions like ischemic heart disease.

Customer Reviews (3)

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Reviews
03/19/2022

    Reliable product, satisfied customer.

    03/28/2021

      Good value for money.

      11/07/2018

        Product exceeded expectations.

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