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Active Recombinant Swine Il6

Cat.No. : Il6-16S
Product Overview : Swine IL-6 was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
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Description : Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. IL-6 is also produced from muscle, and is elevated in response to muscle contraction. It is significantly elevated with exercise, and precedes the appearance of other cytokines in the circulation. Osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. The role of IL-6 as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10.
Source : Yeast
Species : Swine
Form : Lyophilized without carrier protein.
Bio-activity : The biological activity of recombinant swine IL-6 was measured in a cell proliferation assay using the mouse B9 cell line. The ED50 for this effect is typically 1-10 pg/mL.
Molecular Mass : Swine IL-6 has a predicted molecular weight of 20.9 kDa.
AA Sequence : GRLEEDAKGD ATSDKMLFTS PDKTEELIKY ILGKISAMRK EMCEKYEKCE NSKEVLAENN LNLPKMAEKD GCFQSGFNQE TCLMRITTGL VEFQIYLDYL QKEYESNKGN VEAVQISTKA LIQTLRQKGK NPDKATTPNP TTNAGLLDKL QSQNEWMKNT KIILILRSLE DFLQFSLRAI RIM (183)
Purity : >95% as visualized by SDS-PAGE analysis
Applications : The Swine IL-6 protein can be used in cell culture, as an IL-6 ELISA Standard, and as a Western Blot Control.
Storage : Stable for up to twelve months from date of receipt at -20 oC. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20 oC. Avoid repeated freeze/thaw cycles.
Reconstitution : Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
Gene Name : IL6 interleukin 6 (interferon, beta 2) [ Sus scrofa (pig) ]
Official Symbol : IL6
Synonyms : IL6; nterleukin 6 (interferon, beta 2); interleukin-6; IL-6; interleukin-6 protein
Gene ID : 399500
mRNA Refseq : NM_214399
Protein Refseq : NP_999564
UniProt ID : P26893
Chromosome Location : 9q14-q15; 9
Pathway : African trypanosomiasis; Cellular Senescence; Cytokine Signaling in Immune system

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the dosage and usage of Il6? 07/15/2022

The dosage and usage of Il6 will vary according to the disease, and generally require individualized regulation by the physician according to the disease situation.

What are the pharmacokinetic properties of Il6? 06/16/2022

The pharmacokinetic characteristics of Il6 mainly include drug absorption, distribution, metabolism, excretion and other information.

Does Il6 have advantages in the treatment of multiple myeloma? 04/22/2022

Recombinant Il6 protein has a unique therapeutic advantage in the treatment of multiple myeloma. It can promote the proliferation and differentiation of hematopoietic stem cells and inhibit the growth of tumor cells.

Does Il6 have specific therapeutic effects for certain diseases? 05/27/2020

Il6 has specific therapeutic effects for certain diseases, such as rheumatoid arthritis, multiple myeloma and so on.

In which diseases is Il6 widely used? 11/20/2019

This protein is widely used in the treatment of rheumatoid arthritis, pneumonia, multiple myeloma, lymphoma, malignant tumors and other diseases.

What is the effect of Il6 on immune cells? 05/21/2019

The effects of Il6 on immune cells are mainly manifested as promoting cell proliferation and differentiation, regulating immune response, etc.

Customer Reviews (3)

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Reviews
03/05/2022

    Accurate localization and function within the cell.

    01/31/2021

      The binding affinity and affinity constant with the target are high.

      03/12/2020

        Can form a stable micellar structure.

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