Active Recombinant Swine Il6
Cat.No. : | Il6-16S |
Product Overview : | Swine IL-6 was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified. |
- Specification
- Gene Information
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Description : | Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. IL-6 is also produced from muscle, and is elevated in response to muscle contraction. It is significantly elevated with exercise, and precedes the appearance of other cytokines in the circulation. Osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. The role of IL-6 as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10. |
Source : | Yeast |
Species : | Swine |
Form : | Lyophilized without carrier protein. |
Bio-activity : | The biological activity of recombinant swine IL-6 was measured in a cell proliferation assay using the mouse B9 cell line. The ED50 for this effect is typically 1-10 pg/mL. |
Molecular Mass : | Swine IL-6 has a predicted molecular weight of 20.9 kDa. |
AA Sequence : | GRLEEDAKGD ATSDKMLFTS PDKTEELIKY ILGKISAMRK EMCEKYEKCE NSKEVLAENN LNLPKMAEKD GCFQSGFNQE TCLMRITTGL VEFQIYLDYL QKEYESNKGN VEAVQISTKA LIQTLRQKGK NPDKATTPNP TTNAGLLDKL QSQNEWMKNT KIILILRSLE DFLQFSLRAI RIM (183) |
Purity : | >95% as visualized by SDS-PAGE analysis |
Applications : | The Swine IL-6 protein can be used in cell culture, as an IL-6 ELISA Standard, and as a Western Blot Control. |
Storage : | Stable for up to twelve months from date of receipt at -20 oC. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20 oC. Avoid repeated freeze/thaw cycles. |
Reconstitution : | Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein. |
Gene Name : | IL6 interleukin 6 (interferon, beta 2) [ Sus scrofa (pig) ] |
Official Symbol : | IL6 |
Synonyms : | IL6; nterleukin 6 (interferon, beta 2); interleukin-6; IL-6; interleukin-6 protein |
Gene ID : | 399500 |
mRNA Refseq : | NM_214399 |
Protein Refseq : | NP_999564 |
UniProt ID : | P26893 |
Chromosome Location : | 9q14-q15; 9 |
Pathway : | African trypanosomiasis; Cellular Senescence; Cytokine Signaling in Immune system |
Products Types
◆ Lysates | ||
IL6-5224HCL | Recombinant Human IL6 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe dosage and usage of Il6 will vary according to the disease, and generally require individualized regulation by the physician according to the disease situation.
The pharmacokinetic characteristics of Il6 mainly include drug absorption, distribution, metabolism, excretion and other information.
Recombinant Il6 protein has a unique therapeutic advantage in the treatment of multiple myeloma. It can promote the proliferation and differentiation of hematopoietic stem cells and inhibit the growth of tumor cells.
Il6 has specific therapeutic effects for certain diseases, such as rheumatoid arthritis, multiple myeloma and so on.
This protein is widely used in the treatment of rheumatoid arthritis, pneumonia, multiple myeloma, lymphoma, malignant tumors and other diseases.
The effects of Il6 on immune cells are mainly manifested as promoting cell proliferation and differentiation, regulating immune response, etc.
Customer Reviews (3)
Write a reviewAccurate localization and function within the cell.
The binding affinity and affinity constant with the target are high.
Can form a stable micellar structure.
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