Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Ubiquitin and Ubiquitin-like Modifiers

Ubiquitin and Ubiquitin-like Modifiers Background

About Ubiquitin and Ubiquitin-like Modifiers

Ubiquitin is a small protein commonly found in eukaryotic cells. It acts as a key regulator of protein degradation by labeling proteins for degradation via the proteasome pathway. In addition to protein degradation, ubiquitin is involved in other cellular processes such as DNA repair, endocytosis, and immune responses.

Ubiquitin-like modifiers, also known as UBL or UBL proteins, are a major class of eukaryotic post-translational modifiers. It has a similar structure to ubiquitin and acts in a ubiquitin-like manner. UBL attaches to many cellular proteins and other macromolecules, thereby regulating various cellular processes. Examples of ubiquitin-like modifiers include SUMO (small ubiquitin-like modifier), NEDD8 (neural precursor cell expression developmentally downregulated 8), and ISG15 (interferon-stimulated gene 15). These modifiers attach to target proteins and regulate their stability, localization, and interactions.

Ubiquitin and Ubiquitin-like Modifiers - Creative BioMart

Role of the Ubiquitin and Ubiquitin-like Modifiers

Degradation of a protein via the Ubiquitin Proteasome pathway involves two discrete and successive steps: tagging of the substrate protein by the covalent attachment of multiple Ubiquitin molecules (conjugation), and the subsequent degradation of the tagged protein by the 26S proteasome. Ubiquitin is conjugated to substrate proteins via an enzymatic cascade involving E1 (ubiquitin-activating), E2 (ubiquitin-conjugating), and E3 (ubiquitin-ligating) enzymes. This classical function is associated with housekeeping roles, including the regulation of protein turnover, and antigenic-peptide generation. More recently, it has become evident that protein modification by Ubiquitin has non-degradative functions, including involvement in DNA repair and histone modification, vesicular trafficking pathways and endocytosis, and viral budding.

Although Ubiquitin is the most studied, there is a growing family of Ubiquitin-like proteins (UBLs) that modify cellular targets in a pathway that is parallel to but distinct from that of Ubiquitin. These alternative modifiers include: SUMO, NEDD8, ISG15, APG8, APG12, FAT10, UFM1, URM1, FUB1, and Hub1. Proteins conjugated to UBLs are typically not targeted for degradation by the proteasome but rather function in diverse regulatory activities including transcription, DNA repair, signal transduction, and autophagy.

Research Tools for Ubiquitin and Ubiquitin-like Modifiers

Creative BioMart is a leading company specializing in life science research tools and services, providing researchers with ubiquitin and ubiquitin-like modifier-related products and resources, click to view all related molecules/targets and research reagents, please get in touch with us with any questions or requests.

Our Advantages

Our Advantages of Ubiquitin and Ubiquitin-like Modifiers - Creative BioMart

Ubiquitin and ubiquitin-like modifiers play critical roles in regulating a variety of cellular processes, including protein degradation, DNA repair, and signaling, and Creative BioMart is at the forefront of research and development in this area, providing comprehensive resources and services for the study of ubiquitin and ubiquitin-like modifiers.

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends