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AASS

Official Full Name

aminoadipate-semialdehyde synthase
Overview

This gene encodes a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in this gene are associated with familial hyperlysinemia.
Synonyms

AASS; aminoadipate-semialdehyde synthase; alpha-aminoadipic semialdehyde synthase, mitochondrial; LKRSDH; LORSDH; lysine-2-oxoglutarate reductase; aminoadipic semialdehyde synthase; alpha-aminoadipate semialdehyde synthase; lysine-ketoglutarate reductase;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Bovine
Human
Mouse
Rat
Zebrafish

Source

E.coli
E.Coli or Yeast
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
His|T7
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	AASS-0180H	Recombinant Human AASS Protein (Val33-Leu455), N-His-tagged	E.coli	N-His	Val33-Leu455	Inquiry
Mouse	Aass-8112M	Recombinant Mouse Aass protein, His & T7-tagged	E.coli	His/T7	Met477~Leu926 (Accession # Q99K67)	Inquiry
Rat	AASS-390R	Recombinant Rat AASS Protein	Mammalian Cell	His		Inquiry
Rat	Aass-3339R	Recombinant Rat Aass, His-tagged	E.Coli or Yeast	His	926	Inquiry
Rat	AASS-45R	Recombinant Rat AASS Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	AASS-45R-B	Recombinant Rat AASS Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Bovine	AASS-3340B	Recombinant Bovine AASS, His-tagged	E.Coli or Yeast	His	926	Inquiry
Zebrafish	AASS-7710Z	Recombinant Zebrafish AASS	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
AASS Related Articles

AASS involved in several pathways and played different roles in them. We selected most pathways AASS participated on our site, such as Adherens junction, Amoebiasis, Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with AASS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adherens junction	RAC2;FYNA;WASF3B;CREBBP;CDC42;CDH1;SMAD2;ACTB1;MET
Amoebiasis	COL5A1;TNF;SERPINB6B;VCL;IL1R2;LAMA3;PIK3R1;Casp3;C8G
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	ITGAV;CACNA2D2;ITGA10;PKP2;CACNG6;ACTN3;GJA1;CACNB1;ACTG1
Focal adhesion	LAMB1;AKT2L;GSK3AA;DIAPH1;COL6A4;CCND3;ARHGAP5;LAMC3;PIK3CA
Hemostasis	SPARC;KIF11;GATA2;GRB7;DOCK11;HBBE1.1;CD9A;KIFAP3;FN1B
Leukocyte transendothelial migration	PIK3CD;CXCL12;CLDN23;CDH5;MYL5;ROCK2;CDC42;CLDN6;CLDN2
Platelet activation, signaling and aggregation	STXBP3A;TRPC6A;ABHD6B;IGF2B;SRGN;PDPN;TFA;STXBP3;F13A1A.1
Platelet degranulation	BRPF3;SRGN;TFA;SCG3;SERPINF2B;SPARC;MMRN1;GAS6;PLEK

AASS has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, actin filament binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AASS itself. We selected most functions AASS had, and list some proteins which have the same functions with AASS. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II regulatory region sequence-specific DNA binding	ZNF584;TAL1;ZNF711;TAL2;TFAP2E;ARID5B;PCGF6;GATA2A;CDX1B
actin filament binding	VPS16;ADD2;ANXA8;BLOC1S6;SCIN;FSCN2B;LIMA1;TTN;CORO2A
calcium ion binding	CELSR1;NCALDB;CRELD1;EMR4;PCDH2G2;BNIP2;PCDHB1;EFCAB4A;EFHD1
chromatin DNA binding	HIST1H1B;RUVBL2;HIST1H1D;ZIC2;RARA;SLAMF7;CLOCK;EP300;WBP2
ion channel binding	PHPT1;TRAPPC2;FKBP1B;CHERP;NEDD4L;GRINA;ACTN4;RANGRF;SNTA1
ligand-dependent nuclear receptor transcription coactivator activity	FGF2;HMGA1-RS1;PPARGC1B;MED24;ENY2;NCOA3;LRP2BP;MED17;CCDC62
nucleoside binding	ACTN4;PNP;POLA1;AASS;CDA
poly(A) RNA binding	TBCA;NOVA1;RBM5;YTHDC1;RPL28;SNRPD2;PRMT1;RIMS1;TFB1M
retinoic acid receptor binding	PRAMEF1;MED1;HMGA1;RXRA;ASXL1;PRAMEF2;CNOT1;PRAME;HMGA1-RS1

AASS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AASS here. Most of them are supplied by our site. Hope this information will be useful for your research of AASS.

Gatrell, SK; Berg, LE; et al. Tissue distribution of indices of lysine catabolism in growing swine. JOURNAL OF ANIMAL SCIENCE 91:238-247(2013).