ABCE1

it is plausible that cellular stress responses, such as nutrient availability, environmental stresses, or cellular growth signals, could impact ABCE1 function and localization

It directly interacts with eukaryotic release factors eRF1 and eRF3, facilitating the dissociation of post-termination ribosomal complexes. These interactions contribute to the overall coordination of translation termination and ribosome recycling processes.

ABCE1 is evolutionarily conserved across different species, indicating its importance in fundamental cellular processes. It is found in a wide range of organisms, including bacteria, archaea, and eukaryotes.

ABCE1 interacts with PINK1, CNOT4 and PELO. What's more,it probably heterodimerizes with RNASEL; this interaction inhibits RNASEL.

It is known to associate with ribosomes and is generally considered to be a cytoplasmic protein

The three-dimensional structure of ABCE1 has been determined using X-ray crystallography and cryo-electron microscopy techniques. It consists of two main domains: the nucleotide-binding domain (NBD) and the C-terminal domain (CTD)

ABCE1 has been implicated in cellular stress responses. It is involved in stress granule formation, which is a cellular response to various stresses, including oxidative stress and heat shock. Stress granules are dynamic cytoplasmic aggregates that sequester untranslated mRNAs and RNA-binding proteins during stress conditions.

Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway

The NBD binds and hydrolyzes ATP, while the CTD contributes to protein-protein interactions involved in ribosome recycling.

Interacts with HIV-1 proteins Vif and Gag

ABCE1 has been implicated in cellular processes, including ribosome biogenesis, RNA degradation, and RNA interference.

The main function of ABCE1 is to participate in translation termination, which is a crucial step in protein synthesis

ABCE1 participates in multiple cellular pathways and processes. Apart from its role in ribosome recycling, it is also involved in mRNA surveillance, RNA quality control, and the assembly of stress granules.

While ABCE1's primary known roles are in ribosome recycling and mRNA surveillance, emerging evidence suggests it may have additional functions and interactions. Some studies have indicated potential involvement in DNA repair processes and modulation of microRNA activity

Post-translational modifications can impact ABCE1 activity or function. For example, phosphorylation has been shown to modulate ABCE1's interaction with other proteins involved in translation termination and ribosome recycling. 

Pontocerebellar hypoplasia (PCH), Breast cancer and Viral infections are related to ABCE1's involvement.

It is known that ABCE1 activity can be modulated by various factors, including post-translational modifications and interactions with other proteins. 

ABCE1 has been found to interact with several proteins involved in ribosome recycling and RNA metabolism. Some of its known interacting partners include eukaryotic release factors eRF1 and eRF3, as well as other ribosomal proteins.

Belongs to the ABC transporter superfamily. ABCE family.

given its involvement in fundamental cellular processes such as translation termination and ribosome recycling, it is likely to play essential roles in these processes during development and in specific tissues