ABCF2

ABCF2 is involved in specialized cellular processes, particularly in the transport and elimination of substrates from cells. Its primary role is to confer resistance against a wide range of compounds by facilitating their efflux from cells. Additionally, ABCF2 has been implicated in cellular detoxification processes and protection against oxidative stress.

ABCF2 has been implicated in drug resistance or multidrug resistance in cancer cells. It is believed that ABCF2 plays a role in the efflux of chemotherapeutic drugs from cancer cells, reducing their effectiveness. By expelling drugs from cells, ABCF2 can contribute to resistance against multiple drugs and hinder successful cancer treatment.

it is possible that variations in the ABCF2 gene could impact its expression levels or regulatory elements, potentially influencing transporter function. 

It is particularly abundant in tissues with high metabolic activity, such as the liver and kidney, where it is involved in the elimination of potentially toxic compounds.

The cellular function of ABCF2, also known as MRP2 (Multidrug Resistance-Associated Protein 2), is primarily related to the transport of molecules across cellular membranes

It is plausible that conditions involving altered drug sensitivity, impaired detoxification, or disrupted cellular homeostasis could potentially be associated with dysregulation of ABCF2

Transcription factors and signaling pathways play a role in regulating its expression. 

it is plausible that conditions involving altered drug sensitivity, impaired cellular detoxification, or disrupted transport processes could potentially be associated with ABCF2 dysregulation

The popular organisms of ABCF2 are human, rat, A.thaliana, mouse and zebrafish.

ABCF2 is primarily associated with intracellular transport processes rather than intracellular vesicle trafficking. It functions as an ATP-dependent efflux pump, transporting substrates across cellular membranes, including the plasma membrane and intracellular organelles.

ABCF2 belongs to the ATP-binding cassette (ABC) transporter superfamily and is involved in the efflux of a variety of substrates, including drugs, toxins, and endogenous compounds, from cells.

ABCF2 plays a crucial role in cellular detoxification pathways by facilitating the efflux of potentially toxic compounds from cells. It contributes to the elimination of substances such as drugs, toxins, and endogenous metabolites, thereby maintaining cellular homeostasis and protecting cells from potential damage.

Apart from its function as a transporter, ABCF2 may have regulatory roles in cellular processes. For example, it may modulate the cellular response to oxidative stress or play a role in cellular detoxification pathways.

ABCF2 is believed to be expressed in various tissues and cell types, suggesting a broad expression profile

Variations or dysregulation of ABCF2 expression could potentially influence drug response or alter cellular homeostasis

ABCF2 is known to interact with other transporters, such as ABCC2 (Multidrug Resistance-Associated Protein 2), and with scaffolding proteins involved in regulating its localization and function.

ABCF2 is known to transport a wide range of substrates

Phosphorylation, acetylation, or other modifications could potentially influence its transport activity or interactions with binding partners

It may play a role in cellular metabolism, including the transport of metabolic intermediates or waste products. Additionally, ABCF2 is involved in maintaining cellular homeostasis by eliminating potentially harmful substances from cells.

ABCF2 is localized to the plasma membrane and is also found in intracellular organelles involved in transport, such as the endoplasmic。 reticulum and mitochondria.