ABCG5
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Official Full Name
ATP-binding cassette, sub-family G (WHITE), member 5
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Overview
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008] -
Synonyms
ABCG5; ATP-binding cassette, sub-family G (WHITE), member 5; STSL; ATP-binding cassette sub-family G member 5; sterolin 1; sterolin-1; ATP-binding cassette, subfamily G, member 5;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Arabidopsis thaliana (Mouse-ear cress)
- Homo sapiens (Human)
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- His|T7
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Mouse | Abcg5-8150M | Recombinant Mouse Abcg5 protein, His & T7-tagged | E.coli | His/T7 | Asp66~Gly276 (Accession # Q99PE8) |
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| Rat | ABCG5-415R | Recombinant Rat ABCG5 Protein | Mammalian Cell | His |
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| Rat | ABCG5-70R | Recombinant Rat ABCG5 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | ABCG5-70R-B | Recombinant Rat ABCG5 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Arabidopsis thaliana (Mouse-ear cress) | RFL9097AF | Recombinant Full Length Arabidopsis Thaliana Abc Transporter G Family Member 5(Abcg5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-649) |
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| Homo sapiens (Human) | RFL4475HF | Recombinant Full Length Human Atp-Binding Cassette Sub-Family G Member 5(Abcg5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-651) |
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| Mus musculus (Mouse) | RFL14050MF | Recombinant Full Length Mouse Atp-Binding Cassette Sub-Family G Member 5(Abcg5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-652) |
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| Rattus norvegicus (Rat) | RFL19216RF | Recombinant Full Length Rat Atp-Binding Cassette Sub-Family G Member 5(Abcg5) Protein, His-Tagged | E.coli expression system | His | Full Length (1-652) |
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| Zebrafish | ABCG5-6981Z | Recombinant Zebrafish ABCG5 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ABCG5 Related Articles
ABCG5 involved in several pathways and played different roles in them. We selected most pathways ABCG5 participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCG5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCC8;ABCB9;ABCD2;ABCG8;ABCB7;ABCG5;ABCB6;ABCD3A;ABCB1A |
ABCG5 has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCG5 itself. We selected most functions ABCG5 had, and list some proteins which have the same functions with ABCG5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PIP5K1B;GK5;MYH9;ACTB;PDK1;CDK20;MTHFD1B;PAPOLG;CLPB |
| ATPase activity | ATP13A3;NSFB;MYH7;CARNS1;KIF20B;MYO19;IDE;KIF15;KIF2B |
| ATPase activity, coupled to transmembrane movement of substances | ABCC11;ABCD3B;ABCC12;ABCC10;ATP6V1D;ABCA3;ABCD3A;ABCA13;ABCA9 |
| contributes_to cholesterol transporter activity | ABCG5;ABCG8;APOA2;SFRP5;APOA1 |
| nucleotide binding | CDK14;RPS6KAL;RHOAE;Adcy4;CLCN6;PRKCDA;ATP9B;PRKACBB;NT5C1B |
ABCG5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCG5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCG5.
- Q&As
- Reviews
Q&As (12)
Ask a questionIt orginnaly refers to sterolin-1
These four domains are typically expressed as a single protein, usually with domains arranged TMD-NBD-TMD-NBD.
Two highly conserved nucleotide-binding domains (NBDs) and two transmembrane domains (TMDs)
Both ABCG5 and ABCG8 were detected in the epithelium of gall bladder mucosa; the cellular distribution of the signals detected was similar and showed a diffuse cytoplasmic distribution.
The expression of ABCG5/G8 protein is limited to the intestine, liver and gallbladder epithelium.
When more plant sterols (the major type of xenosterols) are ingested, they compete with the bulk cholesterol for solubilization, thereby reducing dietary absorption of cholesterol and lowering plasma cholesterol. However, the majority of xenosterols that enter enterocytes are immediately excreted via ABCG5/G8 back into the intestinal lumen
1. response to ionizing radiation, 2. negative regulation of intestinal phytosterol absorption, 3.xenobiotic transmembrane transport.
The gene called ABCG8 .
To determine the site of action of ABCG5
Inactivating mutations in either G5 cause sitosterolemia, a recessive disorder characterized by hypercholesterolemia, phytosterolemia, and premature coronary artery disease.
ABCG5 and ABCG8 are located on chromosome 2p21. The ABCG5gene spans approximately 28 kb and has 13 exons and 12 introns.
ABCG5 function as a heterodimeric complex (ABCG5/G8) and are responsible for biliary and transintestinal secretion of cholesterol and dietary sterols.
Customer Reviews (3)
Write a reviewThe images shows clear, good.
The package is complete and looks great!
Good performance in shRNA process.
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