Abhd16a
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Official Full Name
ABHD16A abhydrolase domain containing 16A [ Homo sapiens ]
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Overview
A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some aspects of immunity. Alternatively spliced transcript variants have been described. -
Synonyms
abhydrolase domain containing 16A; PP199; BAT5; abhydrolase domain-containing protein 16A; NG26; EC 3.-.-.-; D6S82E; G5; HLA-B associated transcript 5; HLA-B-associated transcript 5; Protein G5;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Cynomolgus Monkey
- Homo sapiens (Human)
- Human
- Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
- Mouse
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Rat
- Rattus norvegicus (Rat)
- Zebrafish
- E.coli
- E.coli expression system
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ABHD16A-10144H | Recombinant Human ABHD1, His-tagged | E.coli | His | 209-558a.a. | |
Human | ABHD16A-090H | Recombinant Human ABHD16A protein, GST-tagged | Wheat Germ | GST | ||
Human | ABHD16A-3039H | Recombinant Human ABHD16A, His-tagged | E.Coli or Yeast | His | 558 | |
Human | ABHD16A-1834HF | Recombinant Full Length Human ABHD16A Protein, GST-tagged | In Vitro Cell Free System | GST | 558 amino acids | |
Mouse | ABHD16A-1129M | Recombinant Mouse ABHD16A Protein | Mammalian Cell | His | ||
Mouse | ABHD16A-214M-B | Recombinant Mouse ABHD16A Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | ABHD16A-214M | Recombinant Mouse ABHD16A Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | ABHD16A-421R | Recombinant Rat ABHD16A Protein | Mammalian Cell | His | ||
Rat | ABHD16A-76R | Recombinant Rat ABHD16A Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | ABHD16A-76R-B | Recombinant Rat ABHD16A Protein Pre-coupled Magnetic Beads | HEK293 | |||
Bos taurus (Bovine) | RFL36962BF | Recombinant Full Length Bovine Abhydrolase Domain-Containing Protein 16A(Abhd16A) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-558) | |
Cynomolgus Monkey | ABHD16A-263C | Recombinant Cynomolgus ABHD16A Protein, His-tagged | Mammalian Cell | His | ||
Cynomolgus Monkey | ABHD16A-13C-B | Recombinant Cynomolgus Monkey ABHD16A Protein Pre-coupled Magnetic Beads | HEK293 | |||
Cynomolgus Monkey | ABHD16A-13C | Recombinant Cynomolgus Monkey ABHD16A Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Homo sapiens (Human) | RFL32763HF | Recombinant Full Length Human Abhydrolase Domain-Containing Protein 16A(Abhd16A) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-558) | |
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) | RFL11872MF | Recombinant Full Length Macaca Fascicularis Abhydrolase Domain-Containing Protein 16A(Abhd16A) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-558) | |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) | RFL15050PF | Recombinant Full Length Pongo Abelii Abhydrolase Domain-Containing Protein 16A(Abhd16A) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-558) | |
Rattus norvegicus (Rat) | RFL32842RF | Recombinant Full Length Rat Abhydrolase Domain-Containing Protein 16A(Abhd16A) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-558) | |
Zebrafish | ABHD16A-6239Z | Recombinant Zebrafish ABHD16A | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
Abhd16a involved in several pathways and played different roles in them. We selected most pathways Abhd16a participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Abhd16a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Abhd16a has several biochemical functions, for example, hydrolase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Abhd16a itself. We selected most functions Abhd16a had, and list some proteins which have the same functions with Abhd16a. You can find most of the proteins on our site.
Function | Related Protein |
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hydrolase activity | NUDT6;ACMSD;Aadacl3;KLK1B5;IRGC;GDPD4;EGFBP2;DDX3;PRSS59.1 |
protein binding | POP7;GMCL1;SEC23B;CETN2;BLNK;ABCG8;PPP2CA;VCAN;NUMBL |
Abhd16a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Abhd16a here. Most of them are supplied by our site. Hope this information will be useful for your research of Abhd16a.
RNF5; DTX2; FAM134C; CREB3; SPAG7; MT-ND4L; HNRNPA1; IFITM1; MLH1; ATP5G3; SAFB; HM13
- Q&As
- Reviews
Q&As (10)
Ask a questionUsing STED microscopy, we can found that mammalian ABHD12 is enriched at the ER membrane30, then checked for the co-localization of ABHD16A with ABHD12. Indeed, we found in Neuro-2a cells, that ABHD16A co-localizes with ABHD12, further confirming that ABHD16A is enriched at the ER membrane.
A complicated hereditary spastic paraplegia (HSP) caused by ABHD16A loss of function pathogenic variants and the subsequent altered phosphatidylserine (PS) metabolism.
The protein deglycosylation studies and the detergent-independent sensitivity of ABHD16A to proteolytic degradation, have suggested this point.
Inhibited by beta-lactone-based lipid inhibitors, such as beta-lactone palmostatin-B
They are DTX2, RNF5, AGPAT3, TMEM147, and FAM134C.
ABHD16A is a 21-exon gene which encodes for the α/β hydrolase domain-containing 16A (ABHD16A) enzyme, which is the main brain phosphatidylserine (PS) hydrolase.
ABHD16A and ABHD12, are the main enzymes responsible for the brain LPS metabolism, as ABHD16A generates LPS while ABHD12 catabolizes them into fatty acid and phosphoserine.
ABHD16A PS lipase deficiency results in intellectual disability, progressive spasticity, abnormal corpus callosum, and white matter anomalies, most likely through the dysregulation of lipid species including lyso-PS.
We found relative to the tubulin protein loading control, that ABHD16A was maximally enriched in the cerebellum, and the olfactory bulb, while ABHD12 is ubiquitously expressed at near equal levels in all the aforementioned brain regions.
ABHD16A has a heterogeneous expression in the murine brain and is enriched in the cerebellum, particularly in the granular layer and the olfactory bulb.
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